Thermo Fisher Scientific CTS Cellmation Common Modules Software User guide

Brand: Thermo Fisher Scientific

Model: CTS Cellmation Common Modules Software

Type: User guide

For Research Use or Manufacturing of Cell, Gene, or Tissue- Based

Products.

CTS™ Cellmation™ Common Modules

Software for DeltaV™ System Installation

USER GUIDE

Catalog Numbers A59196, A59197, A59198

Publication Number MAN0029997

Revision A.0

Life Technologies Holdings Pte Ltd | Block 33 | Marsiling Industrial Estate Road 3 | #07-06, Singapore 739256

Revision history: (English)

Revision Date Description

A.0 25 September

2023 Initial release.

The information in this guide is subject to change without notice.

DISCLAIMER: TO THE EXTENT ALLOWED BY LAW, THERMO FISHER SCIENTIFIC INC. AND/OR ITS AFFILIATE(S) WILL NOT BE

LIABLE FOR SPECIAL, INCIDENTAL, INDIRECT, PUNITIVE, MULTIPLE, OR CONSEQUENTIAL DAMAGES IN CONNECTION WITH OR

ARISING FROM THIS DOCUMENT, INCLUDING YOUR USE OF IT.

NOTICE TO PURCHASER: DISCLAIMER OF LICENSE: Purchase of this software product alone does not imply any license under any

process, instrument or other apparatus, system, composition, reagent or kit rights under patent claims owned or otherwise controlled by

Thermo Fisher Scientiﬁc, either expressly, or by estoppel.

TRADEMARKS: All trademarks are the property of Thermo Fisher Scientiﬁc and its subsidiaries unless otherwise speciﬁed.

CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide 3

TABLE OF CONTENTS

1 PURPOSE AND SCOPE ............................................................................................................................ 4

2 REFERENCES ............................................................................................................................................ 4

3 DEFINITIONS AND ACRONYMS ............................................................................................................... 4

4 SAFETY REQUIREMENTS ........................................................................................................................ 5

5 SOFTWARE INSTALLATION PROCEDURE ............................................................................................ 5

5.1 SIGNATURE LOG ........................................................................................................................................ 5

5.2 PREREQUISITES ......................................................................................................................................... 5

5.3 SOFTWARE INSTALLATION .......................................................................................................................... 7

6 APPENDIX ................................................................................................................................................ 21

6.1 MANUAL CREATION OF ALARM TYPES ....................................................................................................... 21

7 SAFETY .................................................................................................................................................... 26

8 DOCUMENTATION AND SUPPORT ....................................................................................................... 26

4 CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide

1 PURPOSE AND SCOPE

The purpose of this document is to provide instructions for installing the Gibco™ CTS™ Cellmation™

Common Module Software code files and DeltaV™ Live functionality.

Each instrument has its own specific installation instructions. This document will guide the installation

of common objects that are used across all the instruments.

This document will also detail the tests required to verify that the installed configuration has been

imported correctly.

2 REFERENCES

Document Name

Cellmation™ Rotea™ Software Installation Instructions

Cellmation™ CryoMed™ Software Installation Instructions

Cellmation™ Xenon™ Software Installation Instructions

Cellmation™ DynaCellect™ Installation Instructions

Cellmation™ Incubator Software Installation Instructions

CTS™ Cellmation™ Common Software Release Notes

CTS™ Cellmation™ Rotea™ Software Release Notes

CTS™ Cellmation™ CryoMed™ Software Release Notes

CTS™ Cellmation™ Xenon™ Software Release Notes

CTS™ Cellmation™ DynaCellect™ Software Release Notes

CTS™ Cellmation™ Incubator™ Software Release Notes

3 DEFINITIONS AND ACRONYMS

Term & (Acronym) Definition

GT Gene Therapy

SN Sentinel Monitor

HM Hold Monitor

EM Equipment Module

USM Unit Support Module

LND Landing Module

PH Phase

OAR Operator Action Request

MON Monitor

PCC Process Cell Class

INS Installation Instructions

N/A Not Applicable

CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide 5

4 SAFETY REQUIREMENTS

N/A

5 SOFTWARE INSTALLATION PROCEDURE

These installation instructions are designed to be undertaken by a Thermo Fisher Service Engineer or

an engineer fully trained in DeltaV.

5.1 Signature Log

The signature log in Table 5-1 needs to be completed by all personnel involved in installing this

software before any work is commenced.

Table 5-1 – Signature Log

Name (print) Title Initials Signature Date

5.2 Prerequisites

The prerequisites in Table 5-2 should be completed and signed-off before the software installation can

commence.

Table 5-2 – Prerequisites

Item

Number Prerequisites Initials / Date

1. User installing the software must have full Windows Administrator Privileges

and DeltaV Administrator Privileges.

2. User must have access to ProfessionalPLUS Station.

3. If applicable, confirm that it is safe to proceed with the installation by following

the change management process.

Ensure that there are no pending downloads required. Before installing

software, conduct a risk assessment to evaluate the impact of any required

downloads.

6 CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide

Item

Number Prerequisites Initials / Date

Software Backup - ProfessionalPLUS

Export the DeltaV Database.

• In DeltaV Explorer, right-click on the topmost level (i.e., the database

name).

• Note the location of the exported database below (this will differ

between clients and systems)

Path: ____________________________________________________

____________________________________________________

Export the DeltaV Live Database.

• In DeltaV Graphics Studio, select the topmost level (i.e., the

database name) from the Graphics Explorer tab.

• From the “File” menu item, select “Export” and check the following:

• Note the location of the exported database below

Path: ____________________________________________________

____________________________________________________

Check for other CTS Cellmation Software installations if applicable.

If there are no Thermo Fisher Scientific instruments on-site, follow this guide

to install the CTS Cellmation Common Module Software by following this

guide.

CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide 7

Item

Number Prerequisites Initials / Date

Check for previous CTS Cellmation Software installations on the system.

To check for installers present, open windows Control Panel and select

• ‘Programs ->‘Programs and Features’

Check for any “gibco_CTS_Cellmation_...............” installers and note them

below

1. ____________________________________________________

2. ____________________________________________________

3. ____________________________________________________

4. ____________________________________________________

5. ____________________________________________________

If a previous CTS Cellmation Common Software installation is present, then

refer to the latest release of the Common Installer and release note for any

updated common items to be installed.

Common software items can be installed by following this guide. Only the

common items should be overwritten.

10.

If any other previous CTS Cellmation Software installations are present, then

refer to the latest release of the instrument specific installer and release note

for any updated items to be installed.

Instrument specific software items can be installed by following the

instructions in the Installation Guide of the instrument specific installers; only

those items should be overwritten.

IMPORTANT: If you already have DeltaV configured for communication with other instruments, only

select “NO” when prompted about an update unless installing an updated version of the

module to ensure Cellmation’s installation does not negatively impact existing DeltaV

connections! This is the safest way to install Cellmation without risking existing configurations.

5.3 Software Installation

The steps shown in Table 5-3 should be performed on the DeltaV ProfessionalPlus (ProPlus) station

using DeltaV Explorer.

This revision of the installation instructions is applicable to release 2.0.0.

IMPORTANT: The order of component installation listed below must be followed because there

are interdependencies to the imported files! If your installation is unsuccessful, you can retry your

import, but the step sequence should be maintained. Additionally, DO NOT delete any files on the

DeltaV computer that you did not import from the Cellmation Installation Folder.

8 CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide

Table 5-3 – Software Installation Instructions

Step Instructions Initials / Date

Copy the Cellmation Common Installer Package into the folder

“D:\DeltaV\DVData\Import-Export” on the DeltaV computer. The Installer package

will include the installer .exe file and other required files/folders. DO NOT delete or

rename any files/folders in the installer package.

Execute the “gibco_CTS_Cellmation_Common_2.0.0.exe” and perform the

following to complete the installation:

• Right-click on the “gibco_CTS_Cellmation_Common_2.0.0.exe” file and

select “Run as administrator”.

• The welcome screen will appear. Click “Next >” once displayed on the

popup screen.

• Accept the terms of the License Agreement to proceed with the

installation. Click “Next >.”

• The pop-up displays the destination location for the software installation.

Click “Next >”.

• Enter Username, Company Name, and serial number (Reg Code received

with the installer). Click “Next >”.

• After entering a valid Reg Code, the “Install” button will be available. Click

to proceed with the installation. Click “Finish” once complete.

• If an invalid Reg Code is entered, it will show the error message “Invalid

registration code.” Click “OK” and re-enter the correct Reg Code to

proceed.

Note: If the same version of the installer is already present on the system, then a

prompt will appear to uninstall the previous version. Select “OK” to continue

uninstallation and “Cancel” to exit uninstallation. Choose the appropriate option.

Otherwise, uninstall the previous installer before proceeding with the new

installation. Select “Control Panel > Programs and Features” to uninstall the

previous installer.

After successful installation, a folder will be created entitled

“gibco_CTS_Cellmation_Common_2.0.0” with two subfolders, “Displays” and

“FHX,” in the Import-Export folder.

Also, this will automatically copy all the chart files present in the

“Displays/Charts_Common” folder to “D:\DeltaV\DVData\Charts\lib”.

Note: Upon uninstallation of the installer, all the created folders during installation

will be automatically deleted (The entire Installer folder

“gibco_CTS_Cellmation_Common_2.0.0” with subfolders and chart files copied

under “D:\DeltaV\DVData\Charts\lib” will get deleted).

CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide 9

Step Instructions Initials / Date

The displays use the Helvetica font which is not installed as part of DeltaV. To

install the fonts, browse to folder “gibco_CTS_Cellmation_Common_2.0.0\Displays

\Fonts\ OpenType CFF W1G” and select all the files, and then select copy.

Open the Control Panel and browse to ‘Control Panel -> Appearance and

Personalization -> Fonts’.

Paste the fonts.

The Helvetica Neue fonts should now appear in the fonts list.

Steps 5 through 12 (except 6 and 8) provide instructions to import various

packages of code directly into the DeltaV library. The standard import flow is as

follows:

• Open DeltaV Explorer (from Start menu under DeltaV Engineering)

• Navigate to File  Import  Standard DeltaV Format

• FHX files to import are located in D:\DeltaV\DVData\Import-Export\

gibco_CTS_Cellmation_Common_2.0.0\FHX

• Make sure to uncheck ‘Include the license information’ tick box before

confirming to import a component. Click Open.

• This will typically take around one minute. When done, “Import complete”

will appear.

• Note: When importing .fhx files into the database, there may be some file

conflicts that open a pop-up prompt.

• If importing for the first time, select “No to All”.

• If re-importing a file for any reason without deleting its previously

imported copy, make sure to read the pop-up.

From DeltaV Explorer, import the Setup .fhx file from the “FHX” subfolder:

Module Name

gibco_Named_Sets_Common

10 CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide

Step Instructions Initials / Date

Confirm the following are imported into “ThermoGT” Named Sets folder in the

database:

Named Set Name

GT_ACQ_REL

GT_CANCEL_WAIT

GT_Disable_Enable

GT_EM_Types

GT_ID_or_Name

GT_Link_Status

GT_MSG_TYPE

GT_OAR_ACTION

GT_OAR_OPTION

GT_OAR_STATUS

GT_OAR_TYPE_BOI

GT_OAR_VERIFY

GT_Timer_Hold

GT_Timer_Type

GT_WAIT_PROMPT

GT_Yes_No

GT_phase_failures

• Located at DeltaV_System  System Configuration  Setup  Named

Sets  ThermoGT

CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide 11

Step Instructions Initials / Date

Check the existing Alarm Priorities configured.

If the existing alarm priority is using the name PROMPT, skip Step 7. Note that

Prompt Alarm for Cellmation software modules will not have a default assignment

of alarm priority 5 but will take the existing priority value.

If any other Alarm Priority with a value of “5” is not present in the existing

configuration, proceed to Step 7.

If an Alarm Priority with a value of “5” is present in the existing configuration, skip

Step 7 and manually create an Alarm Priority “PROMPT” as below:

• Navigate to DeltaV_System  System Configuration  Setup 

Alarm Preferences  Alarm Priorities

• Right-click and select New Alarm Priority.

• Assign properties as per table below:

Property Value

Name PROMPT

Description Prompt alarm 1

Value Next available numeric value

(Recommended: between 4 to 7)

Auto Acknowledge New Alarms False (Uncheck)

Auto Acknowledge when Inactive True (Check)

Alarm Banner Shows Not Hidden

Suppress sound for acknowledged alarms False (Uncheck)

Note that the alarm priority “Value” can be assigned to the next available numeric

value. It is recommended to choose a number between 4 and 7 as this priority

alarm will be purple in color. Changing this value from the default Cellmation

assignment may not alert the alarms to Operators as intended by Thermo Fisher

Scientific.

From DeltaV Explorer, import the Setup .fhx file from the “FHX” subfolder:

Module Name

gibco_Alarm_Priorities_Common

12 CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide

Step Instructions Initials / Date

Confirm the following Alarm Priority is imported into the “Alarm Priorities” folder in

the database:

Alarm Priority Name

PROMPT

• Located at DeltaV_System  System Configuration  Setup  Alarm

Preferences  Alarm Priorities

Ensure that the following alarm types are not present in the system configuration:

Alarm Type Name

Bypass

Equipment Failure

Fault

Maximum time to wait

Module Error

OAR Horn

OAR Prompt

OPCUA Alarm

Device Error

If any of the above alarm types are present in the existing configuration, skip Step

9 and manually create the alarm types that are not present in the system as per

the instructions in the Appendix.

If any of the above alarm types are not present in the existing configuration,

proceed to Step 9.

From DeltaV Explorer, import the Setup .fhx file from the “FHX” subfolder:

Module Name

gibco_Alarm_Types_Common

CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide 13

Step Instructions Initials / Date

Confirm the following alarm types are imported into the “Alarm Types” folder in the

database:

Alarm Type Name

Bypass

Equipment Failure

Fault

Maximum time to wait

Module Error

OAR Horn

OAR Prompt

OPCUA Alarm

Device Error

10.

From DeltaV Explorer, import the Composite Templates .fhx file from the “FHX”

subfolder:

Module Name

gibco_Composites_Common

Confirm the following modules have been imported into the “ThermoGT” folder:

IMPORTANT: The internal revision, in the INTERNAL_REV parameter, for each

module should match the revision documented below:

Module Name Rev Installed Rev

GT_16_SN_MON 0.1

GT_TIMER 0.1

GT_HM_MON 0.1

GT_OAR_ENG_EM 0.1

GT_OAR_ENG_PH 0.1

• Located at DeltaV_System  Library  Composite Templates 

ThermoGT

14 CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide

Step Instructions Initials / Date

11.

From DeltaV Explorer, import the Control Modules Classes .fhx file from the “FHX”

subfolder:

Module Name

gibco_Control_Module_Classes_Common

Confirm the following modules have been imported into the “ThermoGT” folder:

Note the internal revision in the INTERNAL_REV parameter for each module

should match the revision documented below:

Module Name Rev Installed Rev

GT_USM 0.2

• Located at DeltaV_System  Library  Advanced Definitions  Control

Module Classes  ThermoGT

12.

From DeltaV Explorer, import the Equipment Modules Classes .fhx file from the

“FHX” subfolder:

Module Name

gibco_Process_Cell_Classes

Confirm the following modules have been imported into the “ThermoGT” folder:

Module Name Rev Installed Rev

GT_PCC N/A N/A

• Located at DeltaV_System  Library  Advanced Definitions  Process

Cell Classes  ThermoGT

• Note that this module has no revision parameter.

CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide 15

Step Instructions Initials / Date

13.

On DeltaV Computer using DeltaV Explorer

EIOC assigned IO

Assign a predetermined IP address to the ethernet port P01 and generate a

certificate.

• Navigate to DeltaV_System  System Configuration  Physical

Network Control Network  I/O Network  EIOC Name  P01

• Right-click P01 and select Properties.

• In the Advanced tab, input the predetermined IP address of the DeltaV

System under Primary Connection IP Address.

• In the Certificate tab, select Generate to generate a new certificate.

• Click “OK” to save changes and close the pop-up dialog box.

Application Station assigned IO

• Open Windows Control Panel and browse to “Control Panel\Network and

Internet\Network Connections”.

• Select the Network Interface Card (NIC) that is to be used as the OPC UA

network connection and set the TCP/IPv4 IP address to the predetermined

IP address of the DeltaV System.

• Navigate to Delta V Explorer  DeltaV System  System Configuration

 Physical Network  Control Network  Application Station Name 

OPC UA Client

• Right-click OPC UA Client and select Properties.

• In the Certificate tab, select Generate to generate a new certificate.

• Click “OK” to save changes and close the pop-up dialog box.

Note: If the ethernet port P01 or Application Station OPC UA Client is already

assigned to the predetermined IP address and the certificate has been generated,

skip this step.

16 CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide

Table 5-4 – Displays Installation Instructions

IMPORTANT: If implementing Cellmation Software on a DeltaV system that already has DeltaV Live

Graphics configured for communication with other instruments, only select the comparison state as

“Newer,” “Older” or “Different” and select the Import action “Replace” when it is required to

overwrite the existing graphics items. This will ensure Cellmation Software’s installation does

not negatively impact existing DeltaV Graphics items. This is the safest way to install the

Cellmation Software without risking existing configurations!

DeltaV Live Operator Interface

1. Ensure the Helvetica fonts have been installed before proceeding further.

When importing files into the Graphics Studio, the software lists and compares

them with objects already in the database.

Select the default import option (Create) where the comparison states, “New Item”.

Note that if previous CTS Cellmation Software installations have been performed,

no displays can be selected for import.

From Graphics Studio, import the layout objects from the “Displays” subfolder:

• Layouts

4. Confirm that a folder entitled “Cellmation” has been created in

Graphics Explorer -> Layouts

From Graphics Studio, import the common library objects from the “Displays”

subfolder:

• Library_Common

6. Confirm that a folder entitled “Cellmation” has been created in Library Explorer.

CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide 17

Confirm in Library Explorer that the folder structure matches the one shown below

for the applicable instrument.

Note that additional folders may exist from previous CTS Cellmation Software

installations if applicable.

From Graphics Studio, import the contextual displays from the “Displays”

subfolder:

• Displays_Contextual_Common

Confirm that the folder structure is as shown below in Graphics Explorer. Note that

additional folders may exist from previous CTS Cellmation Software installations if

applicable.

10.

From Graphics Studio, import the common displays from the “Displays” subfolder:

• Displays_Common

11.

Confirm that the folder structure is as shown below in Graphics Explorer.

18 CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide

12. Publish all pending objects.

13.

Open workstation management and follow the directions below in DeltaV Live for a

default installation on each applicable station.

General Properties tab

• Start DeltaV Live in “Full Desktop Mode”.

• Check “Using both DeltaV Operate and DeltaV Live”.

• Select Layout “GT_Layout_16_10” for 23-inch monitor screen or Layout

“GT_Layout_16_9” for 27-inch monitor screen. If you prefer not to use the

Cellmation Layout files, please do not modify the current layout file.

Display Set tab

• Initial Display Set “No Display Set”.

Themes tab

• Select Default Theme and DB (Dark Blue).

14. Save and publish the settings.

CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide 19

15.

Open the display ‘GT_Overview’ in Graphics Studio.

Note that this Display is a user configurable display.

• Modify this display to add all the instrument specific overview icon gems

by following the instrument specific installation guide.

• If a single Overview display cannot fit all of the instrument icons, create

multiple copies of this display as required, re-name it accordingly and save

it.

• The display's navigation feature allows switching between multiple

overview displays.

• Click on the ‘GT_Navigation’ Gem instance on the ‘GT_Overview’ display

and set the Forward Display Name, Forward Arrow Visibility, Backward

Display Name and Backward Arrow Visibility under the “Basic” heading as

per your requirements.

• If there is only one overview display required, the Forward Arrow Visibility

and Backward Arrow Visibility can be set to “False”.

• Save and publish the displays.

20 CTSTM CellmationTM Common Modules Software for DeltaVTM System User Guide

16.

Start DeltaV Live. When the splash screen appears click on it to open the overview

display.

If a blank screen appears without the splash screen, perform the following:

• In Graphics Studio, open the layout file “GT_Layout_16_10”.

• Click on object “Main1” and delete the entry for the Display field.

• Save the layout file.

• Re-enter “GT_Splash” in the Display field.

• Save and publish the layout file.

• Repeat the above steps for the layout file “GT_Layout_16_9”.

17.

The trend chart on the display is configured to extract the historical data from a

Continuous Historian. By default, this is set to “PROPLUS”.

Update the application name “SGT_CHist_Server” in the Library Explorer folder

“GT_Common” with the actual Application Station name of the Historian.

• Set the standard “SGT_CHist_Server” to the applicable Application Station

name of the Historian.

• Save and publish the settings.

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Thermo Fisher Scientific CTS Cellmation Common Modules Software User guide

Brand: Thermo Fisher Scientific

Model: CTS Cellmation Common Modules Software

Type: User guide

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Thermo Fisher Scientific CTS Cellmation Common Modules Software User guide

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