Thermo Fisher Scientific TruTorr II Single-Use Sensor User guide

Brand: Thermo Fisher Scientific

Model: TruTorr II Single-Use Sensor

Type: User guide

TruTorr II Single-Use Sensor User’s

Guide

DOC0065 • Revision A

December 2019

Thermo Scientiﬁc

Contents

Warnings, safety, and warranty information 1

How to use this Guide 3

Chapter 1 TruTorr II single-use sensor overview 4

1.1 Trutorr II Sensor description 4

1.2 Main components 5

1.2.1 TruTorr II Sensor 5

1.2.2 Cable 6

1.2.3 Transmitter 7

Chapter 2 Unpacking and installing the TruTorr II sensor 8

2.1 Unpacking the TruTorr II sensor 8

2.2 Installing the TruTorr II sensor 8

2.3 Installing the transmitter 9

2.3.1 Mechanical installation 9

2.3.2 Electrical installation 10

Chapter 3 Operating information 12

3.1 Overview 12

3.2 TruBio Software pressure controller 12

3.3 Main faceplate 13

3.4 Detail display 14

3.5 Control conﬁguration 17

Chapter 4 Calibration 20

Chapter 5 Troubleshooting 21

5.1 Overview 21

5.2 Troubleshooting fault outputs 21

Chapter 6 Maintenance 22

Thermo Scientiﬁc

Contents

Chapter 7 Speciﬁcations 23

7.1 Ordering speciﬁcations 23

7.2 Measurement speciﬁcations—primary 24

7.3 Transmitter speciﬁcations—primary 25

Chapter 8 Regulatory compliance 26

Warnings, safety, and warranty information

Thermo Scientiﬁc

Warnings, safety, and warranty

information

Congratulations! You have purchased a high-quality Thermo

Scientiﬁc™ product. We have included safety information in this Guide,

based on our knowledge and experience. It is important, however, for

you to work with your safety management personnel to ensure that

this product is integrated into your safety practices. Please take some

time to perform your own job safety analysis in order to identify and

control each potential hazard.

WARNING: Read and understand this User’s Guide before

using this product.

TruTorr II sensors must be properly used and maintained to ensure

they continue to operate within their normal speciﬁcations. The

instructions in this Guide must be adhered to and integrated into

your safety program when using and maintaining Thermo Scientiﬁc

products. Failure to follow the proper instructions may cause

any one of the following situations to occur: loss of life, personal

injury, property damage, damage to the instrument, and warranty

invalidation.

WARNING: Follow all warnings, cautions, and instructions

marked on and supplied with the product.

Inform all personnel in the proper operation and maintenance of the

product. Connect all products to the proper electrical and pressure

sources.

Warranty information

Any warranties, if applicable, covering this equipment exclude:

(a) normal wear and tear; (b) accident, disaster or event of force

majeure; (c) your misuse, fault or negligence; (d) use of the equipment

in a manner for which it was not designed; (e) causes external to

the equipment such as, but not limited to, external puncturing,

power failure or electrical power surges; (f) improper storage and

handling of the equipment; (g) use of the equipment in combination

with equipment or software that we did not supply; (h) equipment

sold to you as ‘used’ products; (i) contact with improperly used or

unapproved chemicals or samples; (j) installation, removal, use,

maintenance, storage, or handling in an improper, inadequate, or

TruTorr II Sensor User’s Guide | 1

Thermo Scientiﬁc

Warnings, safety, and warranty information

unapproved manner, such as, but not limited to, failure to follow

the documentation or instructions in the deliverables or related to

the equipment, operation outside of stated environmental or other

operational speciﬁcations, or operation with unapproved software,

materials or other products; (k) not operating the equipment

according to our operation and maintenance guide; (l) installation of

software or interfacing or use of the equipment in combination with

software or products we have not approved; (m) the performance,

efﬁcacy or compatibility of speciﬁed components; and (n) the

performance of custom equipment or products or speciﬁed

components or achievement of any results from the equipment,

speciﬁed components or services within ranges desired by you

even if those ranges are communicated to us and are described in

speciﬁcations, a quote, or a statement of work.

ADDITIONALLY, ANY INSTALLATION, MAINTENANCE, REPAIR,

SERVICE, RELOCATION OR ALTERATION TO OR OF, OR

OTHER TAMPERING WITH, THE EQUIPMENT PERFORMED BY

ANY PERSON OR ENTITY OTHER THAN US WITHOUT OUR

PRIOR WRITTEN APPROVAL, OR ANY USE OF REPLACEMENT

PARTS WE HAVE NOT SUPPLIED, WILL IMMEDIATELY VOID

AND CANCEL ALL WARRANTIES WITH RESPECT TO THE

AFFECTED EQUIPMENT. IF THE EQUIPMENT IS TO BE USED

IN THE UNITED STATES, WE MAY VOID YOUR WARRANTY IF

YOU SHIP THE EQUIPMENT OUTSIDE OF THE UNITED STATES.

WE DO NOT WARRANTY OR GUARANTEE THAT THE USE OF

THE EQUIPMENT WILL MEET ANY PARTICULAR REGULATORY

REQUIREMENTS, AND WE DO NOT INTEND FOR THE

EQUIPMENT DOCUMENTATION TO BE USED IN SUPPORT OF

YOUR REGULATORY APPROVALS.

Use restrictions

You must use this equipment in accordance with our documentation

and if applicable, with our other associated instructions, including

without limitation, a “research use only” product label or “limited use”

label license. This equipment is intended for research use or further

manufacturing in bioprocessing applications and not for diagnostic

use or direct administration into humans or animals, we do not submit

the equipment for regulatory review by any governmental body or

other organization, and we do not validate the equipment for clinical

or diagnostic use, for safety and effectiveness, or for any other

speciﬁc use or application.

TruTorr II Sensor User’s Guide | 2

Thermo Scientiﬁc

How to use this guide

How to use this Guide

Scope of this publication

This User’s Guide contains information about the Thermo Scientiﬁc™

TruTorr II Single-Use Sensor. It is intended for use by people who may

or may not have experience with Thermo Scientiﬁc systems.

Document change information

Revision Date Section Change made Author

A12/2019 -- Initial release E. Hale,

T. Golightly

Questions about this publication

If you have any questions or concerns about the content of this

publication, please contact technicaldocumentation@thermoﬁsher.

com and your Thermo Fisher Scientiﬁc sales team.

Abbreviations/acronyms

Refer to the list below for deﬁnitions of the abbreviations and

acronyms used in this publication.

ARW Anti-reset windup

BPC BioProcess Container

CO Controller output

EMC Electromagnetic compatibility

FCC Federal communications commission

PHV Process history view

PID Proportional integral derivative

PV Process variable

RoHS Restrictions of hazardous substances

RTD Resistance temperature detector

SP Setpoint

TC Time constraint

USP United States Pharmacopeia

VAB Vessel adapter box

TruTorr II Sensor User’s Guide | 3

Thermo Scientiﬁc

Chapter 1 | TruTorr II single-use sensor overview

TruTorr II single-use

sensor overview

1.1. TruTorr II sensor description

The TruTorr II is a single-use pressure sensor comprised of a

disposable sensor, a cable, and a transmitter. The transmitter

integrates signal processing, power conversion, and a 5-20 mA

output signal for range (4 mA when cable is disconnected for alarm).

The TruTorr II sensor format features a disposable 0.25 or 0.5 in.

diameter sheath that is inserted into a headspace port of a single-

use BioProcess Container (BPC) and that encapsulates the TruTorr

II sensor. Note that this is not a ﬂow-through design, but rather the

sheath ﬁts into the port, and the TruTorr II sensor sits at the end of the

sheath tube.

The TruTorr II sensor is aimed at preventing BPCs from bursting due

to overpressure in the BPC. Typical BPC (greater than 50 L in volume)

headspace pressures should be about 0 psi gauge (1 atm absolute

pressure), and operation above 3 psi gauge is considered unsafe.

Although a typical 50 L BPC will burst at 10 psi gauge, and a 1,000

L bioreactor BPC will burst at 3 to 4 psi gauge, manufacturers rate

the maximum headspace pressure at 0.5 psi gauge for all sizes as a

precaution.

Figures 1.1 and 1.2 illustrate the major components of the TruTorr II

sensor. Note: Figure 1.1 shows the transmitter unit for the original

TruTorr sensor. The new TruTorr II sensor unit is black instead of silver.

TruTorr II Sensor User’s Guide | 4

Thermo Scientiﬁc

Figure 1.1. The original TruTorr

pressure sensor transmitter.

TruTorr II Sensor User’s Guide | 5

The disposable TruTorr II sensor is connected to a feed-thru on the

controller chassis used in your system.

The disposable TruTorr II sensor is pre-inserted into a 0.5 in. port at

the top of a single-use bioreactor BPC, and measures the headspace

pressure of the BPC. The TruTorr II sensor is gamma-irradiated with

the BPC, and thereby provides a fully sterile connection. The TruTorr II

sensor and BPC are both disposed of after a run.

The TruTorr II transmitter provides a 5-20 mA analog output that

indicates the headspace pressure, and a 4 mA output for the alarm.

The TruTorr II transmitter does not have a display or user keypad

because it is intended to be directly used on a control panel, rather

than as a standalone transmitter. It is available as an option within the

TruViu hardware family.

Chapter 1 | TruTorr II single-use sensor overview

Cable

Disposable

sensor

Figure 1.2. Disposable TruTorr II sensor and

cable.

Thermo Scientiﬁc TruTorr II Sensor User’s Guide | 6

1.2.2. Cable

The TruTorr II sensor and transmitter are connected together using a

pre-assembled electrical cable (Figure 1.4), which can be 1.83, 3.05,

or 6.09 meters (6, 10, or 20 feet) long. The wire is shielded in order to

maintain a high signal-to-noise ratio at the transmitter electronics.

Figure 1.4. TruTorr II cables.

Chapter 1 | TruTorr II single-use sensor overview

Figure 1.3. TruTorr II sensors.

1.2. Main components

1.2.1. TruTorr II sensor

The TruTorr II sensor consists of a pressure sensor, a circuit board,

and a molded housing made from gamma radiation resistant, USP

Class VI materials. The TruTorr II sensor is designed to ﬁt in a 0.25 in.

or 0.5 in. tube port. The TruTorr II sensor probe is connected to the

transmitter using an electrical cable either 1.83, 3.05, or 6.09 meters

(6, 10, or 20 feet) long.

Thermo Scientiﬁc

Chapter 1 | TruTorr II sensor overview

TruTorr II Sensor User’s Guide | 7

1.2.3. Transmitter

The TruTorr II electronics are housed inside the transmitter enclosure

(Figure 1.5), and are connected to the TruTorr II sensor probe using

an electrical cable as described above. The transmitter performs

the actual measurement of pressure and related signal processing.

The transmitter also provides a 4-20 mA output for pressure.

Note: Figure 1.5 shows the unit for the new TruTorr II sensor. The

original TruTorr II sensor transmitter is silver instead of black.

Figure 1.5. TruTorr II

sensor transmitter.

Thermo Scientiﬁc

Chapter 2 | Unpacking and installing the TruTorr II sensor

Unpacking and installing

the TruTorr II sensor

2.1 Unpacking the TruTorr II sensor

TruTorr II sensors are inspected and tested prior to shipment from the

factory. In the event that there is damage to the shipping container

(holes or crushing, etc.), we require that a representative of the

shipping carrier is present while you unpack the contents. Damage

caused by shipping is the responsibility of the shipping carrier and all

claims must be routed through their claims department.

Please note the following:

• Carefully unpack the contents from the box.

• Check contents of the box against the packing list to ensure all

parts have been received.

• Inspect each item to ensure there is no damage.

• It is recommended that you keep the shipping package until the

unit has been installed and verified as being fully operational.

2.2 Installing the TruTorr II sensor

The TruTorr II sensor system consists of a disposable sensor, cable,

and transmitter. The disposable TruTorr II sensor is pre-inserted into

the port of a single-use bioreactor (S.U.B.) BPC.

TruTorr II Sensor User’s Guide | 8

Thermo Scientiﬁc

Chapter 2 | Unpacking and installing the TruTorr II sensor

Each TruTorr II sensor is pre-installed in a 0.25 or 0.5 in. port located

at the top of the bioreactor BPC headspace. Therefore, only the cable

needs to be connected.

Line up the registration mark on the cable with the registration mark

on the TruTorr II sensor, and ﬁrmly insert the connector. Figure 2.1

shows a bioreactor vessel with a TruTorr II sensor and cable.

TruTorr II Sensor User’s Guide | 9

Figure 2.1. TruTorr II sensor inserted into a headspace port;

the black cable is connected to the sensor.

The TruTorr II sensor transmitter provides a 4-20 mA analog output:

5 mA = 0 psig, and 20 mA = 7 psig. Anything less than 4.5 mA

indicates a sensor failure or disconnected cable.

2.3 Installing the transmitter

2.3.1 Mechanical installation

The TruTorr II transmitter is intended to be pre-installed in a TruViu™

G3Pro™ (installed in supporting vessel adapter box [VAB]), G3Lite,™ or

G3Lab™ (installed in supporting VAB) system. These transmitters are

not sold as standalone products. The transmitter comes installed on

a DIN rail inside the TruViu cabinet, with 24 VDC power and analog

output already connected to the I/O of the hardware system (see red

and blue connections in Figure 2.2) via a Phoenix™ connector.

Note: Figure 2.2 shows the transmitter unit for the new TruTorr II

sensor. The original TruTorr II sensor transmitter is silver instead of

black.

Thermo Scientiﬁc

Chapter 2 | Unpacking and installing the TruTorr II sensor

TruTorr II Sensor User’s Guide | 10

Figure 2.2. 16-pin connector for power,

4-20 mA output, and sensor cable input.

Power (red)

4-20 mA output (blue)

Sensor cable input

(yellow)

For a TruViu system, the sensor side of the original cable is connected

to the TruTorr II sensor. The other end of the sensor cable sensor

is wired to a bulk head in the cabinet, and is pre-connected to a

Phoenix connector that plugs into the transmitter on the inside of the

cabinet (see yellow connections in Figure 2.2).

2.3.2 Electrical installation

The TruTorr II transmitter has two inputs, (the sensor cable and 24

VDC power), and one output (the 4-20 mA current indicating the

measured pressure). These three primary connections are made

through a 16-pin connector on the front of the transmitter. Figure 2.2

in the previous section shows the three primary connection areas on

the 16-pin connector.

Thermo Scientiﬁc

Chapter 2 | Unpacking and installing the TruTorr II sensor

TruTorr II Sensor User’s Guide | 11

Power supply wiring

For the input power, 24 VDC (± 10%) power with at least 30 mA

current is required. The “+” and “GND” supply wiring should be

observed.

Current loop wiring

The 4-20 mA output is device powered, i.e. the instrument supplies

the 4-20 mA current. Therefore, the TruTorr II transmitter output

should not be connected to a powered 4-20 mA loop that is intended

for two-wire transmitters or devices.

Probe cable wiring

The probe cable requires seven (7) pins on the 16-pin connector. The

primary connections are:

• Sensor power (“+5V” and “GND”); any yellow-colored GND

connection can be used

• Sensor pressure output (“SENS+” and “SENS-”)

• Cable shielding (“SHIELD”); either SHIELD connection can be

used

• I2C communication signals (“SCL” and “SDA”)

• THERM, reserved for future use

Note: Gamma irradiation can affect the turn-on voltage of

the ferroelectric RAM (FRAM) in the TruTorr II sensor. Before

every use, power the TruTorr II sensor on and leave for at least

30 minutes for acclimatization. The transmitter output will be

low (fault, less than 4 mA) until the FRAM turns on.

Thermo Scientiﬁc

Chapter 3 | Operating information

Operating information

3.1 O ve r v i ew

The TruTorr II sensor is primarily operated through the Thermo

Scientiﬁc™ TruBio™ Bioprocess Control Software. The software can

be used to display the current pressure reading, set alarm limits, and

activate alarms or interlocks for the process.

3.2 TruBio Software pressure controller

Information associated with the pressure controller is shown as a

control object on the top of the standard main display (Figure 3.1,

detail in [1]).

TruTorr II Sensor User’s Guide | 12

Figure 3.1. TruBio Software pressure control object box (1) and faceplate (2).

Thermo Scientiﬁc

Chapter 3 | Operating information

TruTorr II Sensor User’s Guide | 13

The control module object box includes the control module

description, process variable, setpoint, cascaded setpoint, an

alarm indication (a colored box appears if an alarm is activated or

unacknowledged), and a mode/interlock indication at the upper right

corner of the object box (display M for Manual mode, A for Auto

mode, C for Cascade mode, L for Local Override, and I for Interlock

active).

3.3 Main faceplate

The user can access the standard or main faceplate for the control

module by clicking on the object box. The main faceplate (Figure 3.2)

allows the user to:

• Observe controller output and process variable

• Change the control mode, controller output, and setpoint

• Open the detail display, control studio, process history view (PHV),

and acknowledge alarms

Figure 3.2. TruBio Software pressure main faceplate.

Close window

Process Variable (PV)

Alarm list

Alarm acknowledgement

Process history view

(PHV) historian

Control

studio

Detail

display

Pin window

Thermo Scientiﬁc

Chapter 3 | Operating information

TruTorr II Sensor User’s Guide | 14

3.4 Detail display

The pressure detail display is accessed from the main faceplate

by clicking on the “Detail display” button found on the bottom left

(Figure 3.2). The detail display has several tab options.

The pressure detail display allows the user to:

• Perform 1 pt. standardization and 2 pt. calibration of the probe

• Set the control loop tuning parameters

• Set setpoint, output, deviation, anti-reset windup (ARW), and

alarm limits

• Enable and/or suppress alarms

• Review sensor diagnostics

• Simulate values

• View and bypass the conﬁgured interlock conditions

The “Calibration” tab (Figure 3.3) allows the user to perform a one-

point standardization (by entering the value), or a full two-point

calibration of the TruTorr II sensor. This is a general TruBio Software

function for a general pressure sensor. Because each TruTorr II sensor

is pre-calibrated at the factory, this function is not necessary when

operating with a TruTorr II sensor. Zeroing the sensor may be a useful

function with the 1 pt. standardize.

The “Limits” tab sets the alarm levels (Figure 3.4). Standard alarms

(HI HI, HI, LO, LO LO) are set for the process variable to deﬁne an

acceptable working range. A deviation from SP alarm (HI or LO)

can also be set for a ﬁner set of warnings. Limits can be set for

the controller output (OUT HI, OUT LO), for the setpoint to prevent

erroneous or non-physical SP values being entered, and for the

ARW for the PID control when the control output exceeds its LO and

HI boundaries. A probe deviation alarm can be set when using two

probes if the readings drift too far apart.

Figure 3.3. TruBio Software pressure detail display: “Calibration” tab.

Thermo Scientiﬁc

Chapter 3 | Operating information

TruTorr II Sensor User’s Guide | 15

The “Alarm Hysteresis” is used to prevent noise spikes in a PV to

cause the same alarm to trip numerous times. Namely, the alarm

value must return within the alarm limit by the amount of the alarm

hysteresis value (as a percentage of a scale) before the associated

active alarm clears. Speciﬁcally, Alarm Hysteresis displays the alarm

deadband value for the loop alarms in percentage of PV scale. An

alarm will not recur, but will remain an active alarm, until the PV has

backed away from the corresponding limit by at least the percentage

of PV scale speciﬁed by this value.

The “Conditional Alarms” button allows the user to set timing on

alarms. “Delay on” is the delay in seconds between an alarm going

off and the alarm condition being activated. “Delay off” is the delay

in seconds between an alarm being deactivated and the alarm

condition being removed. The “enable delay” is the delay in seconds

before activating an alarm, such as what would be used in a batch

process. The hysteresis values allow an error margin for the PV prior

to activating an alarm.

The “Tuning” tab (Figure 3.5) allows the user to view and change

the control loop’s tuning parameters, where Gain, Rate, and Reset

correspond to the PID parameters, TC is the loop time constant (to

ﬁlter noise on the signals), and SP Rate on/off is the rate at which a

loop will adjust its parameters when the SP is changed abruptly (in

engineering units). The “I deadband” disables the Reset (I) of the PID

loop when the PV is within the deadband (P and D control only). The

button in the lower center of the detail display page launches the

auto-tuner. Note: The DeltaV auto-tune requires a special license

from Emerson and can also do a one-point calibration through the

CAL routine.

Figure 3.4. TruBio Software pressure detail display: “Alarm

Limits” and “Conditional Alarms” tabs.

Alarm settings

Vx-PI-VSL

Thermo Scientiﬁc

Chapter 3 | Operating information

TruTorr II Sensor User’s Guide | 16

Figure 3.5. TruBio Software pressure detail

display: “Tuning Parameters” tab.

The “Alarms” tab (Figure 3.6) enables and suppresses the individual

alarms. There is a difference between enabling and suppressing

alarms, speciﬁcally:

• “Enable” will switch on the alarms and log them into the “Alarms

and Events” database. When an alarm occurs, the alarm banner

will ﬂash.

• “Suppress” will not show the alarms.

• “Suppress and Enable” simultaneously will still log the alarms

into the “Alarms and Events” database, but they will no longer be

shown on the alarm banner. A button on the right of the alarm

banner will appear for viewing the suppressed alarms.

Figure 3.6. TruBio Software pressure detail

display: “Alarms” tab.

Vx-PI-VSL

Thermo Scientiﬁc

Chapter 3 | Operating information

TruTorr II Sensor User’s Guide | 17

3.5 Control conﬁguration

The user can set up a pressure control strategy by modifying the

Pressure Conﬁguration Form from the Standard Conﬁguration page

(Figure 3.8). The Pressure Control Conﬁguration Form is shown in

Figure 3.9.

Figure 3.7. TruBio Sofware pressure detail

display: “Interlock” tab.

Vx-PI-VSL

The “Interlock” tab (Figure 3.7) allows the user to bypass an interlock

condition that was set for that speciﬁc control parameter or actuator

in the conﬁguration page. For example, if an interlock is put on

pressure when a HI alarm on the TruTorr II sensor is triggered, i.e.,

the pressure exceeds a value close to the BPC rating, but is not

yet harmful to the BPC and the process is known to survive this

condition, the interlock could be bypassed in this page. Note:

Changing the interlocks may cause the system to operate outside of

the recommended speciﬁcations. In this case, the user should check

with their Thermo Fisher Scientiﬁc representative if they are uncertain

as to the ramiﬁcations of any change.

Page is loading ...

Thermo Fisher Scientific TruTorr II Single-Use Sensor User guide

Brand: Thermo Fisher Scientific

Model: TruTorr II Single-Use Sensor

Type: User guide

Download PDF

report

Thermo Fisher Scientific TruTorr II Single-Use Sensor User guide

Thermo Fisher Scientific TruTorr II Single-Use Sensor User guide

Related papers

Other documents