Roche FLOW Primary Sample Handling User manual

FLOW Primary Sample Handling System and

MagNA Pure 96 System

For general laboratory use.

How to use the

FLOW Primary Sample Handling and

MagNA Pure 96 System Guides 0

Before reading, please review the section "Revision history" in the "Prologue" of each cor-

responding guide for important information.

User Training Guide

Provides detailed step-by-step instructions for routine operation using the main application of the

FLOW Primary Sample Handling Instrument in combination with the MagNA Pure 96 Instrument, includ-

ing instrument startup and shutdown.

Operator’s Guides

The FLOW Primary Sample Handling System Operator’s Guide and the

MagNA Pure 96 System Operator's Guide provide a detailed description of each system, system compo-

nents and all relevant software information not covered by the User Training Guide. For installation re-

quirements, always refer to the Operator’s Guide.

Revision history

Provides updates to the FLOW Primary Sample Handling and MagNA Pure 96 System Guides, including

new supplementary information and corrections to previous editions.

For general laboratory use.

FLOW Primary Sample Handling System and

MagNA Pure 96 System

Addendum 1 to the FLOW Primary Sample

Handling System and MagNA Pure 96 System

Operator’s Manual Version 4.0

Software Version 2.1 July 2016

For general laboratory use

2FLOW Primary Sample Handling System and MagNA Pure 96 System

Updated Information about the FLOW Primary

Sample Handling System

Dear Valued User of the FLOW Primary Sample Handling System

Please be informed that section III Declaration of Conformity in the FLOW Primary Sample

Handling System Operator’s Guide is replaced by the following section:

Approvals

The FLOW Primary Sample Handling System meets the requirements laid down in:

c Directive 2014/30/EU of the European Parliament and Council of 26 February 2014

relating to electromagnetic compatibility (EMC).

c Directive 2014/35/EU of the European Parliament and Council of 26 February 2014

relating to electrical equipment designed for use within certain voltage limits.

c Directive 2011/65/EU of the European Parliament and of the Council of 8 June 2011

on the restriction of the use of certain hazardous substances in electrical and electronic

equipment.

Compliance with the applicable directive(s) is provided by means of the Declaration of

Conformity.

The following marks demonstrate compliance:

Complies with the provisions of the applicable EU directives.

Issued by CSA Group for Canada and the US.

Equipment de Laboratoire /

Laboratory Equipment Equipment de Laboratoire / Laboratory Equipment

If you have any questions regarding the FLOW Primary Sample Handling System, please

contact your Roche Diagnostics representative.

Updated Information about the FLOW Primary Sample Handling System

Published by

Roche Diagnostics GmbH

Sandhofer Straße 116

68305 Mannheim

Germany

1 0716

For general laboratory use.

The Flow System is not available in all territories due to different national regulations.

This document is not intended for use in the USA.

All other product names and trademarks are the property of their respective owners.

FLOW Primary Sample Handling System and

MagNA Pure 96 System User Training Guide

Version 4.0 November 2015

For general laboratory use.

Table of contents

3

Prologue 5

I Document information ................................................................................................................................5

1 Revision history ................................................................................................................................................... 5

2 Edition Notice ...................................................................................................................................................... 5

3 Copyright ............................................................................................................................................................... 6

4 Trademarks ........................................................................................................................................................... 6

II Contact addresses ......................................................................................................................................... 6

III Preamble ............................................................................................................................................................. 6

IV Conventions used in this guide .............................................................................................................. 6

V Warnings and precautions ........................................................................................................................ 9

1 Handling precautions .................................................................................................................................... 10

2 General precautions ....................................................................................................................................... 11

3 Electrical safety ................................................................................................................................................ 13

A Startup 15

1 Starting .............................................................................................................................................................. 15

1.1 Starting the FLOW Primary Sample Handling Instrument ............................................................... 15

1.2 Logging in to the FLOW Primary Sample Handling Control Unit .................................................. 15

1.3 Preparing the FLOW Primary Sample Handling Instrument ........................................................... 16

1.4 Starting the FLOW Primary Sample Handling Instrument Software ............................................ 18

1.5 Starting the MagNA Pure 96 Instrument ............................................................................................... 19

1.6 Starting the MagNA Pure 96 Software ................................................................................................... 20

1.7 Preparing the MagNA Pure 96 System ................................................................................................... 21

B Main applications 23

1 Overview ........................................................................................................................................................... 23

1.1 Procedure ........................................................................................................................................................... 24

1.2 Preconditions for the run ............................................................................................................................. 24

2 Setting up and performing a sample transfer for whole blood samples ..................... 25

2.1 Preparing the samples .................................................................................................................................. 25

2.2 Defining the parameters in the software and loading the instrument deck ............................ 26

2.3 Monitoring a run ............................................................................................................................................. 36

2.4 End of a run ....................................................................................................................................................... 37

2.5 Unloading the FLOW Primary Sample Handling Instrument .......................................................... 38

3 Setting up and performing a purification run of genomic DNA

from whole blood samples 39

3.1 Selecting the waiting order file in the MagNA Pure 96 Software ................................................. 39

3.2 Loading the stage of the MagNA Pure 96 Instrument ...................................................................... 41

3.3 Starting a run .................................................................................................................................................... 49

3.4 Monitoring the run ......................................................................................................................................... 49

3.5 End of a run ....................................................................................................................................................... 49

3.6 Unloading the MagNA Pure 96 Instrument .......................................................................................... 52

C Shutting down the systems 53

1 Shutting down the FLOW Primary Sample Handling System ............................................. 53

2 Shutting down the MagNA Pure 96 System ................................................................................ 54

D Appendix 55

1 Index ................................................................................................................................................................... 55

FLOW Primary Sample Handling System and MagNA Pure 96 System User Training Guide Version 4.0

4

Prologue

Document information

5

Prologue

I Document information

1 Revision history

2 Edition Notice

This User Training Guide is for users of the FLOW Primary Sample Handling System in combination

with the MagNA Pure 96 System.

This User Training Guide is to be used in combination with the following guides:

The FLOW Primary Sample Handling System Operator’s Guide Version 4.0, November 2015

The MagNA Pure 96 System User Training Guide Version 3.0, June 2014

The MagNA Pure 96 System Operator's Guide Version 3.0, June 2014

The Instructions for Use / Method Sheets for specified MagNA Pure 96 Kits

Every effort has been made to ensure that all the information contained in the User Training Guide is cor-

rect at the time of publishing. However, Roche Diagnostics GmbH reserves the right to make any changes

necessary without notice as part of ongoing product development.

User Train-

ing Guide

Version

Software Versions Revision

Date

Changes

V1.0 FLOW Primary Sample Handling

Software

V1.0 October 2013 First edition

MagNA Pure 96 Software V2.0

V2.0 FLOW Primary Sample Handling

Software

V1.2 July 2014 Update:

New software version 1.2

Generic tube type and sam-

ple type enabled

Editorial corrections

MagNA Pure 96 Software V2.0

V3.0 FLOW Primary Sample Handling

Software

V2.0 January 2015 Update:

New software versions

Improved error handling

(FLOW Primary Sample

Handling Instrument)

New surveillance features

(MagNA Pure 96 Instru-

ment)

Editorial corrections

MagNA Pure 96 Software V3.0

V4.0 FLOW Primary Sample Handling

Software

V2.1 November 2015 Update:

New software version 2.1

Optimized user interface

Editorial corrections

MagNA Pure 96 Software V3.0

FLOW Primary Sample Handling System and MagNA Pure 96 System User Training Guide Version 4.0

Contact addresses

6

3 Copyright

Information in this document is subject to change without notice. No part of this document may be

reproduced or transmitted in any form or by any means, electronic or mechanical, for any purpose, with-

out the express written permission of Roche Diagnostics GmbH.

Questions or comments regarding the contents of this User Training Guide can be directed to your local

Roche Diagnostics representative.

4 Trademarks

MAGNA PURE is a trademark of Roche.

Other brands or product names are trademarks of their respective holders.

II Contact addresses

III Preamble

Before setting up operation of the FLOW Primary Sample Handling Instrument or the

FLOW PCR Setup Instrument in primary sample handling mode and the MagNA Pure 96 Instrument, it

is important to read this User Training Guide, the FLOW Primary Sample Handling System Operator's

Guide and the MagNA Pure 96 System Operator's Guide thoroughly and completely. Non-observance of

the instructions provided or performing any operations not stated in the user documentation could pro-

duce safety hazards.

IV Conventions used in this guide

Text conventions

To present information consistently and make it easy to read, the following text conventions are used in

this guide:

Manufacturer Roche Diagnostics GmbH

Sandhofer Straße 116

68305 Mannheim

Germany

Distribution Roche Diagnostics GmbH

Sandhofer Straße 116

68305 Mannheim

Germany

Numbered list Steps in a procedure that must be performed in the order listed.

Italic type Used for operating instructions for the

FLOW Primary Sample Handling Instrument Software or the

MagNA Pure 96 Software. In addition, important notes and information notes are

shown in italics.

Blue italic type Refers to a different section in this guide that should be consulted.

[] Square brackets indicate keys on the keyboard.

<> Angle brackets indicate variables to be replaced with appropriate values.

Prologue

Conventions used in this guide

7

Abbreviations

For more information, refer to the FLOW Primary Sample Handling System Operator's Guide, chapter F,

section Glossary.

Product names

The FLOW Primary Sample Handling Instrument Software can be installed and executed on a

FLOW PCR Setup System. Therefore, the workflow of the FLOW Primary Sample Handling System and

the MagNA Pure 96 System can also be established using a FLOW PCR Setup System in primary sample

handling mode.

In the following sections, this document references the FLOW Primary Sample Handling Instrument only

to facilitate readability.

The technical specifications of the FLOW Primary Sample Handling System also apply to the

FLOW PCR Setup System when operated in primary sample handling mode.

Symbols

In this User Training Guide the following symbols are used as visual signals:

Symbol Meaning Description

WARNING This symbol indicates that non-compliance with instructions or

procedures could lead to physical injury or even death or could

cause damage to the instrument.

HOT SURFACE This symbol is used to label potentially hot instrument surfaces.

BIO HAZARD This symbol indicates that certain precautions must be taken

when working with potentially infectious material.

DANGEROUS

ELECTRICAL VOLTAGE

This symbol indicates the danger of personal injury due to dan-

gerous electrical voltage. Refers to an imminent danger that

may result in death or serious personal injury.

ULTRAVIOLET LIGHT This symbol indicates that the

FLOW Primary Sample Handling Instrument contains high-

energy ultraviolet lamps that can cause serious temporary or

persistent eye and skin irritation. Never expose unprotected

eyes or skin to the UV light.

LASER BEAM This symbol indicates the presence of a class 2 laser.

KEEP HANDS CLEAR This symbol indicates the risk of crushing hands in movable

parts.

IMPORTANT NOTE This symbol indicates information critical to the success of the

procedure or use of the product.

INFORMATION NOTE This symbol indicates additional information about the current

topic or procedure.

 This symbol indicates a procedure to be continued on the next

page.

This symbol indicates the end of a procedure.

FLOW Primary Sample Handling System and MagNA Pure 96 System User Training Guide Version 4.0

Conventions used in this guide

8

Symbols used on the instruments or components of the control units

Symbol Meaning Description

MANUFACTURER OF

DEVICE

On the instrument type plate.

CE MARK The CE mark on the instrument type plate indicates conformity

with requirements of the directives relevant for this instrument.

CSA MARK FLOW Primary Sample Handling Instrument:

On the instrument type plate.

China RoHS Mark FLOW Primary Sample Handling Instrument:

On the instrument type plate.

cUL MARK MagNA Pure 96 Instrument:

On the instrument type plate.

KEEP HANDS CLEAR MagNA Pure 96 Instrument:

On the front panel behind the load flap of the instrument.

The process station moves in a vertical direction. This causes

the risk of crushing hands in this movable part.

ULTRAVIOLET LIGHT FLOW Primary Sample Handling Instrument:

On the vertical cover, in the middle, and on the UV lamp.

ULTRAVIOLET LIGHT MagNA Pure 96 Instrument:

On the supporting frame behind the maintenance flap of the

instrument.

LASER BEAM FLOW Primary Sample Handling Instrument:

Indicates the presence of a class 2 laser.

On the autoload.

DANGEROUS

ELECTRICAL VOLTAGE

FLOW Primary Sample Handling Instrument:

On the left side of the instrument near the power connection.

MagNA Pure 96 Instrument:

On the back of the instrument near the power box.

BIO HAZARD FLOW Primary Sample Handling Instrument:

On the left side of the vertical cover and on the waste station.

MagNA Pure 96 Instrument:

On the front panel behind the load flap of the instrument.

HOT SURFACE FLOW Primary Sample Handling Instrument:

On the UV lamp.

MagNA Pure 96 Instrument:

On the front panel behind the load flap of the instrument.

Prologue

Warnings and precautions

9

V Warnings and precautions

In an emergency, immediately press the main switch on the front of an instrument to switch the instru-

ment off.

This instruments are electromechanical devices that could cause electric shock or injury if not operated

according to the procedures described in this User Training Guide, the

FLOW Primary Sample Handling System Operator's Guide and the MagNA Pure 96 System Operator's

Guide.

Failure to comply with the instructions in this User Training Guide will void the manufacturer’s warranty

and may expose the operator to danger.

It is essential that the following safety information required for installation and operation of the instru-

ments is carefully read and observed. Please ensure that this safety information is accessible to all person-

nel working with the FLOW Primary Sample Handling System and the MagNA Pure 96 System. A copy

of this guide is available on the control unit of the instrument and is accessible for all operators.

The trained field service engineer and the laboratory administration share the responsibility for the instal-

lation qualification and the operation qualification, that is, verification and training. The process qualifi-

cation is the sole responsibility of the laboratory.

WARNING FLOW Primary Sample Handling Instrument:

On the right side of the vertical cover.

Robotic arm: Moving arm inside cover; aborts the run if the

cover is opened. Do not move the robotic arm by hand.

Connection to pc: Use only the appropriate shielded cables.

USB connection: Having a total cable distance of more than

5 m, signals can be interfered.

MagNA Pure 96 Instrument:

On the instrument type plate; consult the accompanying docu-

ments for important safety-related information such as warn-

ings and precautions.

WEEE Electrical and electronic equipment marked with this symbol is

covered by the European directive WEEE.

The symbol denotes that the equipment must not be disposed

of in the municipal waste system.

Symbol Meaning Description

FLOW Primary Sample Handling System and MagNA Pure 96 System User Training Guide Version 4.0

Warnings and precautions

10

1 Handling precautions

Do not let water or chemicals come into contact with any electrical components. Water or

chemicals may cause damage and will void your warranty.

Unplug the equipment if it will not be used for extended periods of time.

When using the equipment, follow generally accepted procedures for quality control and

method development.

Do not attempt to disassemble the equipment. Repairs must be performed by a trained

field service engineer. The equipments contain no operator-serviceable parts.

Do not modify any part of the equipment. Modification may cause fire or malfunction, or

may void the manufacturer’s warranty.

Use only original FLOW Primary Sample Handling Instrument and

MagNA Pure 96 Instrument specific parts and tools, for example, carriers, racks, tips, and

waste bags. Commercially available liquid vessels, such as primary tubes, may of course

be used.

Do not change or modify the pipetting routines provided in the

FLOW Primary Sample Handling Instrument Software or the purification protocols provid-

ed in the MagNA Pure 96 Software. This will lead to malfunction of the

FLOW Primary Sample Handling Instrument or the MagNA Pure 96 Instrument.

Anti-virus software is not provided. It is therefore essential to take precautions to ensure

that any software loaded onto the system is free of malicious code (viruses, Trojan horses,

etc.). It is recommended to install only Roche software on the control units.

Do not place your hands into the instrument when it is switched on.

Follow all safety instructions printed on or attached to the instruments.

Observe all general safety precautions that apply to electrical instruments.

Do not access any electrical parts while an instrument is connected to the mains.

Never touch switches or power cord with wet hands.

Always wear safety goggles and gloves when dealing with toxic, caustic or infectious

materials.

Make sure the main switch is freely accessible.

Warning of electric shock. Keep all covers closed while the instruments are connected to

the main power supply.

Spraying liquid on electrical parts can cause a short circuit and result in fire. Keep the

covers closed while the instruments are connected to the main power and do not use

spray in the vicinity of the instruments.

Warning of explosion from sparks. Keep all potentially inflammable or explosive material

(for example,anesthetic gas) away from the instruments.

All biological material is to be regarded as potentially infectious. Handling and disposal of

such material should be performed according to local safety guidelines. Spills should be

immediately disinfected with an appropriate disinfectant solution to avoid spreading con-

tamination to laboratory personnel or equipment.

Please refer to the corresponding Operator’s Guides, chapter Maintenance to find instruc-

tions for cleaning the instruments.

FLOW Primary Sample Handling Instrument:

The instruments contain high-energy ultraviolet lamps that can cause serious temporary or

persistent eye and skin irritation. Never expose unprotected eyes or skin to the UV light.

MagNA Pure 96 Instrument:

Do not insert hands or fingers into either of the holes provided for discarding waste liquids

(on the right of the stage). If the reagent-dispensing nozzle head moves suddenly, it may

strike and injure your hand or fingers.

MagNA Pure 96 Instrument:

The instruments contain high-energy ultraviolet lamps that can cause serious temporary or

persistent eye and skin irritation. Never expose unprotected eyes or skin to the UV light.

Prologue

Warnings and precautions

11

2 General precautions

The FLOW Primary Sample Handling Instrument and the MagNA Pure 96 Instrument are designed to

ensure safe operation. However, since biological sample material may be processed in the instruments,

there is a possible risk of infection. Therefore, when handling potentially infectious material, always fol-

low standard safety procedures and bear in mind the following steps to minimize the chance of contami-

nation or infection.

The instruments should not be used to analyze infectious materials unless additional safety measures

to ensure safe sample handling (for example, placing the instrument in a laboratory with the appropri-

ate safety level, or using a sample handling protocol that allows external sample lysis) are taken before-

hand.

Do not allow reagents containing guanidine thiocyanate to contact sodium hypochlorite (bleach) solu-

tion or acids. These mixtures produce a highly toxic gas.

Wear disposable gloves, laboratory coats, and eye protection when handling specimens and reagents.

Immediately disinfect spills with an appropriate disinfectant solution to avoid spreading contamina-

tion to laboratory personnel or equipment.

If you are handling infectious, potentially infectious or any other dangerous material on the instru-

ments, you must follow your country-specific guidelines and national, federal, state and local regula-

tions.

Discard unused reagents and waste (solid and liquid) in accordance with national, federal, state and

local regulations.

Material Safety Data Sheets (MSDS) are available online at www.e-labdoc.roche.com, or upon request

from the local Roche office.

After sample preparation is complete, remove and autoclave all disposables if you were working with

infectious sample material.

If this guide deviates from your national guidelines in any way, always follow your national guidelines.

This may mean, for example, that you must use additional or alternative disinfectants or cleaning

methods.

FLOW Primary Sample Handling Instrument:

The UV lamp is hot while the instrument is operating. Do not touch the housing of the UV

lamp.

MagNA Pure 96 Instrument:

The incubator of the process station is hot while the instrument is in operation.

Do not touch the surface of the heating block. The block is hot enough (up to +100°C)

to cause immediate burning.

Do not stare into the laser beam or view it directly with optical instruments.

Any additional software must not be installed on the control units of the instruments. Installa-

tion of any additional software on the control units presents the risk of interference with soft-

ware and software modules of the instruments, and could affect result security.

Make sure the main switch of the instruments is freely accessible in each case.

Incorrect location of the instruments can cause incorrect results and damage to the

equipment parts. If applicable, follow the installation instructions carefully. Moving the

instruments must be performed only by qualified Roche service personnel.

FLOW Primary Sample Handling System and MagNA Pure 96 System User Training Guide Version 4.0

Warnings and precautions

12

Loading

When pouring liquid into the containers, ensure that there is no foam on the surface of the liquid.

Foam may cause pipetting problems.

Do not overfill reagent containers, tubes, or other liquid containers.

Do not fill up partially consumed tip trays with tips from other trays. Tip trays should be loaded into

the Rack-TIP-CAR-480-A00, for 480 tips or MagNA Pure 96 Tip Racks as they are provided in the

original package. The tip trays are individually labeled with a barcode for identification.

Work routine

Do not try to open the vertical cover of the FLOW Primary Sample Handling Instrument or the front

cover of the MagNA Pure 96 Instrument during a run because the system will abort and this may

cause the loss of data.

All disposables are intended for single use only. Never use a disposable more than once (even after

cleaning it) as this would lead to unexpected and unreliable results.

Do not empty the tip waste during a run.

Do not leave tips on the pipetting channels for a long period of time (for example, overnight). A daily

maintenance procedure will remove the tips. For more information, refer to the

FLOW Primary Sample Handling System Operator's Guide and the MagNA Pure 96 System Operator’s

Guide, chapter D, section Operator Maintenance.

Disinfection and decontamination

For sole disinfection purposes, you may use commercially available disinfection reagents (please con-

tact the respective distributors in your country for more information). To remove DNases and/or

RNases, use a suitable decontamination reagent such as LTK-008, and afterwords wipe with water. Be

aware that decontamination agents do not disinfect. Please follow the instructions of the respective

manufacturer. For more information on decontamination, refer to the

FLOW Primary Sample Handling System Operator's Guide and the MagNA Pure 96 System Opera-

tor’s Guide, chapter D, section "Operator Maintenance").

FLOW Primary Sample Handling Instrument:

Do not use disinfecting materials that contain hypochlorite (Javel water, Chlorox) or bleaching fluids.

MagNA Pure 96 Instrument:

Bleach can be used for disinfection and removal of contaminating nucleic acids and nucleases at the

same time. If a specimen or other biohazardous material spills on the instrument or any of the racks,

clean the area, carrier or rack with a 10% (v/v) bleach solution (0.5% sodium hypochlorite) and then

with a 70% ethanol solution.

Danger of explosion through sparks. Keep all potentially inflammable or explosive material (for

example, anesthetic gas) away from the instruments.

Spraying liquid on electrical parts can cause a short circuit and result in a fire.

Keep the cover closed while the instruments are connected to the mains and do not use

sprays in the vicinity of the instruments. During firefighting operations, disconnect the instru-

ments from the mains.

Do not manipulate the instruments.

Prologue

Warnings and precautions

13

After cleaning and disinfecting, decontaminate the instruments using the built-in UV lamps. For more

information on UV decontamination, refer to the FLOW Primary Sample Handling System Operator's

Guide and the MagNA Pure 96 System Operator’s Guide, chapter D, section Operator Maintenance.

The FLOW Primary Sample Handling Instrument and the MagNA Pure 96 Instrument are no fully

airtight devices. In the MagNA Pure 96 Instrument there is an air flow under the instrument platform.

Although all air flow from the platform is filtered through the dust filters, it cannot be guaranteed that

the platform atmosphere never leaves the instrument without prior filtration by the filter. For more

information, refer to the MagNA Pure 96 System Operator’s Guide, chapter B, section "Main Compo-

nents".

Therefore both instruments do not have the same functionality as a laminar flow biological safety cab-

inet and should not be used for analysis of infectious sample material that can be transmitted by air,

unless additional safety measures ensure safe sample handling.

3 Electrical safety

Please observe the warnings regarding interactions and non-recommended functions. Also bear in

mind the potential scope for misuse; it is advisable to draw attention to the possible consequences.

The FLOW Primary Sample Handling Instrument and the MagNA Pure 96 Instrument are

designed in accordance with Protection Class I (IEC). The chassis/housing of each instru-

ment is connected to protection earth (PE) by a cable. For protection against electric shock

hazards, the instruments must be directly connected to an approved power source such as a

three-wire grounded receptacle for the 115/230 V line. Where only an ungrounded

receptacle is available, a qualified electrician must replace it with a properly (PE) grounded

receptacle in accordance with the local electrical code. No extension must be used.

Any break in the electrical ground path, whether inside or outside the instrument, could cre-

ate a hazardous condition. Under no circumstances should the operator attempt to modify or

deliberately override the safety features of the instrument. If the power cable becomes

cracked, frayed, broken, or otherwise damaged, it must be replaced immediately with the

equivalent part from Roche Diagnostics.

FLOW Primary Sample Handling System and MagNA Pure 96 System User Training Guide Version 4.0

14

Startup

Starting

15

A

Starting the FLOW Primary Sample Handling Instrument

Startup 0

1 Starting

Before preparing a run, start both instruments and the control units.

1.1 Starting the FLOW Primary Sample Handling Instrument

The main switch of the FLOW Primary Sample Handling Instrument is located on the front of the instru-

ment at the bottom left. For a detailed description of the instrument parts, refer to the

FLOW Primary Sample Handling System Operator’s Guide, chapter B, section System description.

To start the FLOW Primary Sample Handling Instrument

1.2 Logging in to the FLOW Primary Sample Handling Control Unit

To log in to Microsoft Windows on the control unit, follow the steps below.

Press the main switch.

The LEDs on the vertical cover flash alternately.

When the initialization procedure has finished successfully, the LEDs stop flashing.



Switch on the monitor and the control unit. The operating system is started.

Log in to Microsoft Windows:

Click the Operator icon.

Enter the following password: OperF1OW



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Roche FLOW Primary Sample Handling User manual

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