Richard-Allan Scientific

Subsidiary of Thermo Fisher Scientific

4481 Campus Drive, Kalamazoo, MI 49008

Phone: 1 (800) 522-7270

Phone: + 1 (269) 544-5600

www.thermoscientific.com/pathology

Anatomical Pathology

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Thermo Shandon Limited

Subsidiary of Thermo Fisher Scientific

Tudor Road, Manor Park,

Runcorn, Cheshire WA7 1TA, UK

Phone: +44 (0) 1928 534 050

Fax: + 44 (0) 1928 534 049

Thermo Scientic™ Richard-Allan Scientic Concentrated Neutral Buffered

maintained in each gallon of the Concentrated Neutral Buffered Formalin. The product is free from particulate

at room temperature (25°C) and stable to freezing temperatures. During winter months, however, a white

precipitate may form upon shipping. Storage at room temperature for 24 to 48 hour period will ensure elimina-

tion of the precipitate. Unlike 37% formaldehyde and some other formalin concentrates, the precipitate will go

back into solution.

Concentrated Neutral Buffered Formalin should never be used undiluted. This will result in incomplete fixation

especially within the core of the tissue. Excessive cross-linking will occur on the periphery of the tissue causing

the inner areas to be absent of fixation. This will also deter the influx of other reagents into the inner tissue

because of the excessive crosslinking matrix.

Concentrated Neutral Buffered Formalin is a good alternative to making 10% Neutral Buffered Formalin in the

3. Pour 1 gallon of Concentrated Neutral Buffered Formalin into container or carboy.

4. Fill container or carboy with 4 gallons distilled or deionized water.

5. Replace cap on container or carboy.

6. If the container or carboy has a spigot, position container so that the spigot overhangs on the counter.

7. Dispense liquid.

Warnings and Precautions

See Material Safety Data Sheets for warnings and precautions, as well as R & S code definitions.

See container labels for warnings and precautions.

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