Roche SYMPHONY S-plus User manual

Brand: Roche

Model: SYMPHONY S-plus

Type: User manual

SYMPHONY

Rethink H&E

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SYMPHONY Operator Manual

Ventana Medical Systems, Inc.

www.ventana.com

SYMPHONY Operator Manual

copied, reproduced, or distributed by any means or for any purpose without the express prior written permission of

Ventana Medical Systems, Inc. (Ventana

Trademark

VENTANA, OPTISURE, SYMPHONY, Ventana HD H&E Logo, VANTAGE, and the Ventana Logo are

trademarks of Roche. All other trademarks are the property of their respective owners.

Licenses

Ventana’s products may be governed by one or more license agreements, including third-party licenses. Users of

the products or software discussed in this operator manual, and other Ventana products are subject to the terms of

such licenses. Other products, components, modules, features and/or functions referenced in this operator manual

that are not part of the SYMPHONY base products or package of products discussed herein may not be received or

used by any person unless the relevant license fees are paid and the relevant license agreements are duly executed.

Disclaimer and Waiver of Warranty

Ventana makes no warranty of any kind with regard to the material contained in this operator manual, including but

not limited to, the implied warranties of merchantability and fitness for a particular purpose. Receipt or use of the

products discussed herein are subject to the product warranty, statement of intended use, and other regulatory

information, if any, contained in this manual.

This publication is furnished “as is” and is for informational use only and should not be construed as a commitment

of any kind by Ventana. Every effort has been made to ensure that the information contained in this operator

manual is accurate as of the time of printing. However, Ventana shall not be liable for errors or omissions contained

in this operator manual or for any damages, including incidental or consequential damages, in connection with the

furnishing, performance, or use of the material in this operator manual.

Information in this operator manual is subject to change without notice. Ventana reserves the right to make any

changes to this operator manual as necessary as part of ongoing product development. Users should check the latest

version of this operator manual for any updates or additions to the information herein.

Governing Law

All copyrights, trademarks, patents, and license agreements shall be governed and construed in accordance with the

laws of the State of Arizona and the laws of the United States, unless otherwise provided in agreements governing

such copyrights, trademarks, patents, or licenses.

Contact

Ventana Medical Systems, Inc.

1910 E. Innovation Park Drive

Tucson, Arizona 85755

USA

+1 520 887 2155

+1 800 227 2155 (USA)

www.ventana.com

Roche Diagnostics GmbH

Sandhofer Strasse 116

D-68305 Mannheim

Germany

SYMPHONY Operator Manual Regulatory Notices

14886EN Rev L v

Regulatory Notices

Compliance with Standards and Directives

The SYMPHONY instrument is manufactured and certified to comply by Ventana Medical

Systems, Inc. having tested it to following safety standards:

EN 61010-1 Safety requirements for electrical equipment for measurement, control, and

laboratory use – Part 1: General requirements.

EN 61010-2-101 Safety requirements for electrical equipment for measurement, control, and

laboratory use – Part 2-101: Particular requirements for in vitro diagnostic

(IVD) medical equipment

EN 61326-2-6 Electrical equipment for measurement, control and laboratory use - EMC

requirements – Part 2-6: Particular requirements - In vitro diagnostic (IVD)

medical equipment; IEC 61326-2-6:2005

IEC 61010-2-010 Safety Requirements for Electrical Equipment for Measurement, Control, and

Laboratory Use, Part 2-010: Particular Requirements for Laboratory Equipment

for the Heating of Materials

The following markings demonstrate Regulatory compliance:

Complies with European Union (EU) Directive 98/79/EC

Tested and certified to USA and Canadian national versions of IEC 61010-1:2002

and all international versions by CSA International; CB certificate # CA/7795/CSA

N20091

Regulatory Notices SYMPHONY Operator Manual

vi Ventana Medical Systems A Member of the Roche Group

Federal Communications Commission (FCC) Information

This equipment has been tested and found to comply with the limits for a Class A digital device,

pursuant to Part 15 of the FCC rules. These limits are designed to provide reasonable protection

against interference when the equipment is operated in a commercial environment. This equipment

generates, uses, and can radiate radio frequency energy, and if not installed and used in accordance

with the instruction manual, may cause interference to radio communications. Operation of this

equipment in a residential area is likely to cause interference, in which case the user will be

required to correct the interference at his own expense. However, there is no guarantee that

interference will not occur in a particular installation. If this equipment does cause interference to

radio or television reception, which can be determined by turning the equipment off and on, the

user is encouraged to try to correct the interference by one or more of the following measures:

• Reorient or relocate the receiving antenna.

• Increase the separation between the equipment and receiver.

• Connect the equipment into an outlet on a different circuit from that into which the

receiver is connected.

• Consult the dealer or an experienced radio/TV technician for help.

CAUTION: Changes or modifications not expressly approved by the party responsible for

compliance with part 15 of the FCC rules could void the user’s authority to operate the equipment.

Canadian Department of Communications (DOC) Information

This digital apparatus does not exceed the Class A limits for radio noise emissions from digital

apparatuses as set out in the Radio Frequency Regulations of the DOC.

SYMPHONY Operator Manual Preface and Intended Use

14886EN Rev L vii

Preface

The Ventana SYMPHONY system has been designed to provide Ventana customers with a new

generation of H&E slide preparation. The SYMPHONY system is a high throughput staining

system with the capability to fully automate the process of drying, paraffin removal, staining, glass

coverslipping, and slide curing. SYMPHONY Solutions are biologic stains intended for standard

histology laboratory use and are specifically designed to be used in conjunction with the

SYMPHONY system.

Intended Use

The instrument, reagents, and consumables are intended for in vitro diagnostic (IVD) use.

Ventana Medical System’s (Ventana) SYMPHONY system and SYMPHONY Solutions are

intended for use in qualitative histological staining to demonstrate nuclear and cytoplasmic

morphology and staining patterns of fixed tissue components in paraffin-embedded tissue.

Preface and Intended Use SYMPHONY Operator Manual

viii Ventana Medical Systems A Member of the Roche Group

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SYMPHONY Operator Manual    Table of Contents 
 
    14886EN Rev L  ix 
Table of Contents 
Regulatory Notices ................................................................................................................................. v 
Compliance with Standards and Directives .................................................................................... v 
Federal Communications Commission (FCC) Information ............................................................ vi 
Canadian Department of Communications (DOC) Information ...................................................... vi 
Preface .................................................................................................................................................. vii 
Intended Use ......................................................................................................................................... vii 
Table of Contents ................................................................................................................................... ix 
List of Figures ....................................................................................................................................... xiii 
1  Safety Information ................................................................................................... 1 
SYMPHONY System Safety Compliance ............................................................................................... 1 
Safety Training........................................................................................................................................ 1 
Reagent Handling ................................................................................................................................... 2 
Laser Safety ............................................................................................................................................ 2 
Labels ..................................................................................................................................................... 3 
2  Introducing the SYMPHONY System and Solutions ............................................. 5 
Rethink Productivity ................................................................................................................................ 5 
An improved workflow .................................................................................................................... 5 
Ease of use ..................................................................................................................................... 5 
Maximum flexibility ......................................................................................................................... 5 
Rethink Safety ........................................................................................................................................ 5 
Lab Safety ...................................................................................................................................... 5 
Safe and ergonomic design ............................................................................................................ 6 
Patient Safety ................................................................................................................................. 6 
Rethink Quality ....................................................................................................................................... 6 
Rethink H&E ................................................................................................................................... 6 
3  SYMPHONY Instrument and Operation Overview ................................................. 7 
Slide Tray ................................................................................................................................................ 8 
System Features..................................................................................................................................... 9 
SYMPHONY Touchscreen ................................................................................................................... 10 
4  Installation Requirements ..................................................................................... 11 
Instrument Specifications ..................................................................................................................... 11 
Space Requirements ............................................................................................................................ 11 
Clearance ..................................................................................................................................... 11 
Delivery Access ............................................................................................................................ 11 
Water Requirements ............................................................................................................................. 12 
Deionized Water Quality ............................................................................................................... 12 
Water Flow Rate ........................................................................................................................... 12 
Supply Location and Connection .................................................................................................. 12 
Electrical Requirements ........................................................................................................................ 12 
Voltage/Amperage ........................................................................................................................ 12 
Receptacle Type ........................................................................................................................... 12 
Location ........................................................................................................................................ 12 
Effluent Management Requirements .................................................................................................... 13 
Effluent Disposal Connections ..................................................................................................... 13 
Solutions Capture Module ............................................................................................................ 13 
Laboratory Exhaust Specifications ............................................................................................... 13 
Communication Requirements ............................................................................................................. 13 
Printer Connection ........................................................................................................................ 13 
Network Connection ..................................................................................................................... 13 
Instrument Leveling .............................................................................................................................. 14 

Table of Contents    SYMPHONY Operator Manual 
 
x  Ventana Medical Systems A Member of the Roche Group 
5  Consumables and Accessories ............................................................................ 15 
SYMPHONY Solutions ......................................................................................................................... 15 
Alcohol .......................................................................................................................................... 15 
OPTISURE Glass Coverslips ............................................................................................................... 15 
Accessories .......................................................................................................................................... 16 
Storage Requirements .......................................................................................................................... 16 
Flammable Storage ...................................................................................................................... 16 
Room Temperature Solution Storage........................................................................................... 16 
OPTISURE Glass Coverslip Cassette Storage ............................................................................ 16 
Required Accessories ........................................................................................................................... 16 
The Slide Tray .............................................................................................................................. 17 
Desiccant Filter ............................................................................................................................. 17 
Microscope Slide Specifications ................................................................................................... 17 
Fixative Specifications .................................................................................................................. 17 
6  Instrument Setup ................................................................................................... 19 
User Setup ............................................................................................................................................ 20 
User Privileges ............................................................................................................................. 20 
Accessing User Maintenance ....................................................................................................... 20 
Setting Operator Privileges .......................................................................................................... 21 
Setting up a New User ................................................................................................................. 21 
Deleting a User ............................................................................................................................. 22 
System Setup ....................................................................................................................................... 22 
Alarm Setup .......................................................................................................................................... 23 
Set Other Alarms .......................................................................................................................... 24 
Setting a Default Protocol ..................................................................................................................... 25 
Creating a Protocol ....................................................................................................................... 25 
Updating a Protocol ...................................................................................................................... 27 
Deleting a Protocol ....................................................................................................................... 27 
Staining Protocol Options ............................................................................................................. 27 
Autostart ............................................................................................................................................... 27 
Using the Autostart Feature ......................................................................................................... 27 
7  Instrument Operation ............................................................................................ 29 
Preparing to Use SYMPHONY Solutions ............................................................................................. 29 
Continuous Access Solutions ....................................................................................................... 29 
Loading and Unloading SYMPHONY Solutions ........................................................................... 29 
Loading Bag-in-Box SYMPHONY Solutions ................................................................................ 29 
Unloading Bag-in-Box SYMPHONY Solutions ............................................................................. 30 
Recycling Information ................................................................................................................... 31 
Opening SYMPHONY CLEAR Solution ............................................................................................... 31 
Using the SYMPHONY Strap Wrench.......................................................................................... 31 
Uninstalling the SYMPHONY CLEAR Bottle ................................................................................ 32 
Loading SYMPHONY CLEAR Solution ........................................................................................ 32 
Filling the Alcohol Reservoir ................................................................................................................. 33 
Use of the OPTISURE Coverslipper..................................................................................................... 34 
Loading OPTISURE Glass Coverslip Cassettes .......................................................................... 35 
Loading Slides and Slide Trays .................................................................................................... 35 
Loading Slides into the Slide Tray ................................................................................................ 36 
Loading and Running Slide Trays ................................................................................................ 36 
Canceling the Tray ....................................................................................................................... 37 
Unloading Slide Trays .................................................................................................................. 37 
Hibernate and Standby Modes ............................................................................................................. 38 
Displaying SYMPHONY Information .................................................................................................... 39 
Finding a Tray in the System ................................................................................................................ 40 
QA/QC Options ..................................................................................................................................... 40 
Logs ...................................................................................................................................................... 41 

SYMPHONY Operator Manual    Table of Contents 
 
    14886EN Rev L  xi 
Online Help ........................................................................................................................................... 41 
8  Maintenance ........................................................................................................... 43 
Daily Maintenance ................................................................................................................................ 43 
Desiccant Filter ............................................................................................................................. 43 
Removing a Used Desiccant Filter ............................................................................................... 44 
Check All SYMPHONY Solutions ................................................................................................. 45 
Removing Broken Coverslips ............................................................................................................... 45 
Removing Empty OPTISURE Cassettes...................................................................................... 46 
SYMPHONY N2+ Cleaning Kit ............................................................................................................. 46 
9  Recovery Procedures ............................................................................................ 49 
Before Attempting to Recover Trays .................................................................................................... 49 
Removing Trays from the IntelliQue ............................................................................................. 50 
Removing Trays from the Table ................................................................................................... 50 
Removing Trays from the Modules .............................................................................................. 52 
Removing trays from the Stainers, Prep Oven, and Curing Oven ............................................... 52 
Removing Trays from the Drying Oven ........................................................................................ 53 
Removing Trays from the Coverslipper ........................................................................................ 53 
Removing Trays from the BarCode Reader / Slide Detect Module ............................................. 54 
Removing Trays from the Portal ................................................................................................... 54 
10  Troubleshooting ..................................................................................................... 55 
Error Messages Generated During System Operation......................................................................... 55 
System Issues Without a System Error Message ................................................................................ 55 
System Issues With a System Error Message ..................................................................................... 57 
System Warnings.................................................................................................................................. 59 
Power Failure ........................................................................................................................................ 61 
APPENDIX A: Performance Characteristics of the SYMPHONY System and 
Solutions ...................................................................................................................... 63 
Inter-run Reproducibility ....................................................................................................................... 63 
Intra-run Reproducibility ....................................................................................................................... 63 
Sensitivity/Specificity ............................................................................................................................ 63 
Verification of SYMPHONY Staining Performance Across Various Fixation Types and Times........... 63 
Verification of SYMPHONY Staining Performance on various Tissue Thicknesses ............................ 64 
APPENDIX B: SYMPHONY Solutions Capture Module (SSCM) ............................... 65 
Module Specifications ........................................................................................................................... 65 
Module Design ...................................................................................................................................... 65 
Space Requirements ............................................................................................................................ 65 
Module Operations ............................................................................................................................... 66 
SSCM Containers ......................................................................................................................... 66 
Capturing SYMPHONY effluent ................................................................................................... 67 
SSCM Maintenance...................................................................................................................... 68 
SSCM Safety ................................................................................................................................ 68 
 

Table of Contents SYMPHONY Operator Manual

xii Ventana Medical Systems A Member of the Roche Group

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SYMPHONY Operator Manual    List of Figures 
 
    14886EN Rev L  xiii 
List of Figures 
Figure 1. Hot Surface Label ................................................................................................................................................................................................................. 3 
Figure 2. Safety Alert Label.................................................................................................................................................................................................................... 3 
Figure 3. Class 1 Laser .......................................................................................................................................................................................................................... 3 
Figure 4. High Voltage Label.................................................................................................................................................................................................................. 3 
Figure 5. Flammable Material Label ...................................................................................................................................................................................................... 3 
Figure 6. Separate Collection for Electrical and Electronic Equipment ................................................................................................................................................. 3 
Figure 7. Slide Tray Features................................................................................................................................................................................................................. 8 
Figure 8. Component Overview with Labels, Closed View of the SYMPHONY System....................................................................................................................... 9 
Figure 9. Component Overview with Labels, Open View of the SYMPHONY System ......................................................................................................................... 9 
Figure 10. Touchscreen Overview ....................................................................................................................................................................................................... 10 
Figure 11. NEMA 6-20R Receptacle Illustration .................................................................................................................................................................................. 12 
Figure 12. System Effluent Connection ............................................................................................................................................................................................... 13 
Figure 13. Setup Icon ........................................................................................................................................................................................................................... 19 
Figure 14. Main Setup Screen with Five Setup Icons .......................................................................................................................................................................... 19 
Figure 15. About SYMPHONY Screen ................................................................................................................................................................................................ 20 
Figure 16. Setup Icon ........................................................................................................................................................................................................................... 20 
Figure 17. Operators Setup Icon .......................................................................................................................................................................................................... 21 
Figure 18. User Login Screen .............................................................................................................................................................................................................. 21 
Figure 19. Add User Icon ..................................................................................................................................................................................................................... 21 
Figure 20. User Setup Screen.............................................................................................................................................................................................................. 22 
Figure 21. Delete User Icon ................................................................................................................................................................................................................. 22 
Figure 22. System Setup Icon .............................................................................................................................................................................................................. 22 
Figure 23. System Setup Screen ......................................................................................................................................................................................................... 23 
Figure 24. Alarm Setup ........................................................................................................................................................................................................................ 23 
Figure 25. Alarm Setup Screen ............................................................................................................................................................................................................ 24 
Figure 26. Audible Alarm Setup Screen............................................................................................................................................................................................... 24 
Figure 27. Setup Icon ........................................................................................................................................................................................................................... 25 
Figure 28. Protocol Setup Icon ............................................................................................................................................................................................................ 25 
Figure 29. Protocol Setup Screen ........................................................................................................................................................................................................ 26 
Figure 30. Update Protocol Screen ...................................................................................................................................................................................................... 26 
Figure 31. Setup Icon ........................................................................................................................................................................................................................... 27 
Figure 32. Protocol Setup Icon ............................................................................................................................................................................................................ 27 
Figure 33. Autostart Disabled Icon ....................................................................................................................................................................................................... 27 
Figure 34. Autostart Enabled Icon ....................................................................................................................................................................................................... 28 
Figure 35. Loading Bag-in-Box (Pull Yellow Seal) ............................................................................................................................................................................... 30 
Figure 36. Aligning Plastic Top ............................................................................................................................................................................................................ 30 
Figure 37. Using the SYMPHONY Strap Wrench ................................................................................................................................................................................ 31 
Figure 38. Removing the SYMPHONY CLEAR Bottle ........................................................................................................................................................................ 32 
Figure 39. Loading the SYMPHONY CLEAR Bottle ............................................................................................................................................................................ 33 
Figure 40. SYMPHONY CLEAR Bottle Installed ................................................................................................................................................................................. 33 
Figure 41. Alcohol Reservoir, Sight Glass, and Alcohol Level Index .................................................................................................................................................. 34 
Figure 42. Filling the Alcohol Reservoir ............................................................................................................................................................................................... 34 
Figure 43. OPTISURE Glass Coverslip Cassette ................................................................................................................................................................................ 35 
Figure 44. Loading the OPTISURE Cassette ...................................................................................................................................................................................... 35 
Figure 45. Loading Slides into a Tray. ................................................................................................................................................................................................. 36 
Figure 46. Load Tray Icon .................................................................................................................................................................................................................... 36 
Figure 47. Loading a Tray into the SYMPHONY System .................................................................................................................................................................... 37 
Figure 48. Run Start Icon ..................................................................................................................................................................................................................... 37 
Figure 49. Cancel Tray Button ............................................................................................................................................................................................................. 37 
Figure 50. Tray Unload Icon................................................................................................................................................................................................................. 38 
Figure 51. Removing a Tray from the SYMPHONY System ............................................................................................................................................................... 38 
Figure 52. Stop Icon ............................................................................................................................................................................................................................. 38 
Figure 53. System and Status Icons in Status View Screen ............................................................................................................................................................... 39 
Figure 54. Back Icon ............................................................................................................................................................................................................................ 39 
Figure 55. Find Tray Icon ..................................................................................................................................................................................................................... 40 
Figure 56. Tray Overview Screen ........................................................................................................................................................................................................ 40 

List of Figures    SYMPHONY Operator Manual 
 
xiv  Ventana Medical Systems A Member of the Roche Group 
Figure 57. QC Icon ............................................................................................................................................................................................................................... 40 
Figure 58. Reports Icon ........................................................................................................................................................................................................................ 41 
Figure 59. Runtime Log Icon ................................................................................................................................................................................................................ 41 
Figure 60. Help Icon ............................................................................................................................................................................................................................. 41 
Figure 61. Desiccant Filter ................................................................................................................................................................................................................... 43 
Figure 62. Appearance of New and Exhausted Desiccant Filters ....................................................................................................................................................... 44 
Figure 63. Disengaging the Left Quick Release Tab ........................................................................................................................................................................... 44 
Figure 64. Disengaging the Right Quick Release Tab ........................................................................................................................................................................ 44 
Figure 65. Removing the Cartridge ...................................................................................................................................................................................................... 45 
Figure 66. Coverslip Drawer ................................................................................................................................................................................................................ 46 
Figure 67. Cassette Discard Bin .......................................................................................................................................................................................................... 46 
Figure 68. Main Screen with Maintenance Option Enabled ................................................................................................................................................................ 47 
Figure 69. Starting the N2+ Cleaning Kit Procedure ........................................................................................................................................................................... 47 
Figure 70. N2+ Cleaning Kit Activity Screen ........................................................................................................................................................................................ 48 
Figure 71. Slack in the Elevator Cable................................................................................................................................................................................................. 49 
Figure 72. Using the IntelliQue Access Tool to Open the IntelliQue Door .......................................................................................................................................... 50 
Figure 73. X and Y Hooks on IntelliQue Table .................................................................................................................................................................................... 50 
Figure 74. Manually Removing a Tray From a Module ....................................................................................................................................................................... 51 
Figure 75. Manually Moving a Tray From the Drying Oven or Portal to the Transportation Table ..................................................................................................... 51 
Figure 76. The Elevator Leadscrew and Elevator Knob ...................................................................................................................................................................... 51 
Figure 77. Manually Disengaging a Tray From the Transportation Table for Removal Via the IntelliQue ......................................................................................... 52 
Figure 78. Manually Removing a Tray From the Drying Oven ............................................................................................................................................................ 53 
Figure 79. Coverslipper Dispensing Hooks Locked in Position for Manual Removal of Tray From Coverslipper Module ................................................................. 53 
Figure 80. Manually Opening the Portal .............................................................................................................................................................................................. 54 
Figure 81. Inside the SYMPHONY Solutions Capture Module ............................................................................................................................................................ 65 
Figure 82. SSCM Container Correct Configuration ............................................................................................................................................................................. 66 
Figure 83. Engaging the Quick Disconnect Fittings ............................................................................................................................................................................. 66 
Figure 84. SSCM module status lights................................................................................................................................................................................................. 67 
Figure 85. SSCM Status Indicator on the SYMPHONY Touchscreen ................................................................................................................................................ 67 
 
 

SYMPHONY Operator Manual 1 Safety Information

14886EN Rev L 1

1 Safety Information

WARNING: Unplug the unit before relocating it.

SYMPHONY System Safety Compliance

All users of the Ventana SYMPHONY system must read and understand this user manual. For

optimal user safety and operational benefit, the SYMPHONY system should be used only in an

environment where good clinical practice guidelines are followed.

All warnings and cautions that appear in the manual or on equipment must be observed to help

ensure personal safety and to help prevent damage to either the instrument or equipment connected

to it. If equipment is used in a manner not specified by the manufacturer, the protection provided

by the equipment may be impaired or otherwise compromised.

NOTE: No operator serviceable parts are behind the door that houses the Touchscreen.

Safety Training

All operators must be trained in safe use of the instrument. After such training, operators must

ensure the following before attempting to use the system:

• The equipment must be connected to a grounded outlet.

• The equipment must be connected to a voltage source that is in agreement with the rating

label.

• Instruments not used in a manner specified by Ventana may impair protection provided

by the equipment.

• Replacement of internal filters and tubing is performed by Ventana service personnel.

• Operators must keep their hands clear of the moving parts of the instrument.

• Operators must keep their hands clear of potential pinch points.

• Operators must keep their hands clear of all internal hot surfaces.

• Operators must consult the Material Safety Data Sheets for safe handling and disposal of

reagents used with the instrument.

• Operators must comply with local and state codes for safe handling and disposal of

reagents used with the instrument.

WARNING: Good electrical safety practice should be observed at all times.

Make sure the unit is unplugged before relocating it or attempting to move it. It is recommended

that absorbent mats be placed around the system to avoid risk of slipping or electrical shock in the

event of reagent spills or leaks.

1 Safety Information SYMPHONY Operator Manual

2 Ventana Medical Systems A Member of the Roche Group

Reagent Handling

Some, but not all, reagents used in the SYMPHONY system are flammable and/or may be

considered an irritant. Use good clinical practice guidelines when handling reagents.

WARNING: Flammable. All flammable liquids must be handled and stored according to all

applicable regulations.

Some, but not all, reagents used in the SYMPHONY system are flammable. The system must be

connected to a dedicated ventilation system and situated in a well-ventilated area per CLIA

guidelines, free from any ignition sources in the area.

WARNING: Do not squeeze or tilt the Bag-in-Box reagents after removing from the system. A

small amount of fluid may leak through the pierced septum.

Laser Safety

CAUTION: Use of controls or adjustments to performance of procedures other than those

specified herein may result in hazardous laser light exposure.

SYMPHONY Operator Manual 1 Safety Information

14886EN Rev L 3

Labels

The following labels are affixed to the instrument to indicate particular hazards. Labels are not to

scale.

Warning:

Hot Surface

Figure 1. Hot Surface Label

Warning:

Safety Alert

Figure 2. Safety Alert Label

IEC: Class 1 Laser

Figure 3. Class 1 Laser

Warning:

High Voltage

Figure 4. High Voltage Label

Warning:

Flammable Material

Figure 5. Flammable Material Label

WEEE: New Waste

Figure 6. Separate Collection for Electrical and Electronic Equipment

Class 1 Laser Product

per IEC/EN 60825-1 Ed.2:2007

1 Safety Information SYMPHONY Operator Manual

4 Ventana Medical Systems A Member of the Roche Group

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SYMPHONY Operator Manual 2 Introducing the SYMPHONY System and Solutions

14886EN Rev L 5

2 Introducing the SYMPHONY System and

Solutions

Ventana’s SYMPHONY system and SYMPHONY Solutions are designed and optimized to bring

enhanced productivity, safety, and quality to your laboratory when used as instructed. The

SYMPHONY system greatly improves efficiency and accuracy for greater productivity, higher

quality biologic slides, and a better user experience.

Rethink Productivity

The SYMPHONY system is an advanced, completely automated solution for H&E slide

preparation. SYMPHONY is the only truly “One-Touch H&E” slide-staining system and

provides:

An improved workflow

• All-in-one system, automating H&E processing including drying, paraffin removal,

staining, coverslipping, curing

• Greater walk-away time than any other system

• Unattended operation for up to 500 slides

• Improved overall laboratory productivity through the elimination of non-value added

work

• Less labor, higher productivity

• SmartTrack automated tracking for reagents and consumables

• Error reduction through better information management

Ease of use

• Easy to use software and an intuitive graphic user interface require minimal training

and/or re-training

• Fast and easy consumable management and ready to use reagents

• Error reduction through reagent tracking and automated reporting

Maximum flexibility

• Automation of all steps in the process

• Flexibility in workflow design and ability to streamline processes

Rethink Safety

The SYMPHONY system is designed to improve the safety of the working environment in the

histology laboratory.

Lab Safety

• Environmentally friendly

− Xylene free

− Low-toxicity reagents

2 Introducing the SYMPHONY System and Solutions SYMPHONY Operator Manual

6 Ventana Medical Systems A Member of the Roche Group

Safe and ergonomic design

• Lower exposure to reagents

• No handling of open reagents

• Low toxicity fumes

• Ergonomically designed

• Effluent designed to go direct to drain

Patient Safety

• Protection against tissue cross-contamination

• Positive identification of patient samples

Rethink Quality

The usual methods for H&E have remained unchanged for nearly 40 years. Reagent degradation,

sample carryover, and labeling errors seriously compromise stain quality, laboratory productivity

and ultimately, patient care.

Ventana’s SYMPHONY system integrates unique reagent and automation technology to produce a

HIGH DEFINITION H&E (HD H&E) stain of exceptional quality, consistency, and

reproducibility.

• The Ventana HD H&E provides enhanced diagnostic visualization through the

SYMPHONY instrument’s discrete slide staining system that delivers fresh, quality

controlled reagent to each patient slide.

• The exceptionally high quality of Ventana’s HD H&E slide offers the potential to expand

the diagnostic value beyond the ordinary “dip and dunk” H&E.

Rethink H&E

Ventana’s HIGH DEFINITION H&E offers improved diagnostic visualization with superior

clarity and discrimination of microanatomic detail especially prominent in:

• Cytoplasmic membranes

• Nuclear detail

• Collagen fibers

• Keratin

• Nuclear membranes

• Sub-cellular structures, including

− Cilia

− Brush borders

− Squamous intercellular bridges

− Nuclear grooves

− Vacuoles

− Apoptotic bodies

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Roche SYMPHONY S-plus User manual

Roche SYMPHONY S-plus User manual

Roche SYMPHONY S-plus User manual

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