Richard-Allan Scientific
Subsidiary of Thermo Fisher Scientific
4481 Campus Drive, Kalamazoo, MI 49008
Phone: 1 (800) 522-7270
Phone: + 1 (269) 544-5600
www.thermofisher.com/pathology
Anatomical Pathology
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Thermo Shandon Limited
Subsidiary of Thermo Fisher Scientific
Tudor Road, Manor Park,
Runcorn, Cheshire WA7 1TA, UK
Phone: +44 (0) 1928 534 050
Fax: + 44 (0) 1928 534 049
Thermo Scientic Shandon Formal-Fixx Ready-to-Use 10% Neutral
Buffered Formalin and Thermo Scientic Shandon Formal-Fixx
Concentrate Phosphate-Free
Instructions for Use
For in vitro diagnostic use.
For xation of pathology specimens.
Thermo Scientic™ Shandon™ Formal-Fixx™ Ready-to-Use and Thermo Scientic Shandon Formal-Fixx Concentrate
are neutral buffered formalins designed for use with light and electron microscopy. The
phosphate-free buffering system in both prevents the formation of free formic acid, and its associate artifact,
formalin pigment.
The osmolarity of these xatives allows them to be used not only for light microscopy, but for electron microscopic
studies as well. This eliminates the need to presort specimens for EM.
Formal-Fixx Ready-to-Use is a 10% neutral buffered formalin that is premixed and ready to use from the
container. Formal-Fixx Concentrate is easily diluted to become a 10% neutral buffered formalin.
Instructions for Use
1. Formal-Fixx Ready-to-Use is to be used full strength.
2. Formal-Fixx Concentrate needs to be diluted. Mix 1 part of the concentrate with 4 parts distilled or deionized
water. A one liter bottle of concentrate will make 5 liters of 10% neutral buffered formalin.
3. Use as a routine histologic xative. For optimum results, the minimum tissue/xative ratio should range from
1:15 to 1:20, and specimens should be placed into xative immediately following removal from the patient for
a period of time that will ensure adequate xation.
4. Specimens may be stored in these solutions; they will not cause excessive shrinkage or hardening.
Storage
Store at room temperature. Do not store with hydrochloric acid. Keep containers tightly closed when not in use.
Warnings and Precautions
FOR IN VITRO DIAGNOSTIC USE.
OSHA GHS
DANGER!
Combustible liquid. Causes skin irritation. May cause an allergic skin reaction. Causes serious eye damage.
Suspected of causing genetic defects. May cause cancer. May cause damage to organs.
Prevention
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood.
Use personal protective equipment as required. Wash face, hands and any exposed skin thoroughly after handling.
Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Do not breathe
dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Keep away from heat/
sparks/open ames/hot surfaces. - No smoking.
Response
IF exposed or concerned: Get medical attention/advice.
Skin
IF ON SKIN: Wash with plenty of soap and water. Take off contaminated clothing and wash before reuse. If skin
irritation or rash occurs: Get medical advice/attention.
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
Fire
In case of re: Use CO2, dry chemical, or foam for extinction.
Storage
Store locked up. Store in a well-ventilated place. Keep cool.
Disposal
Dispose of contents/container to an approved waste disposal plant.
WARNING. Cancer and Reproductive Harm - https://www.p65warnings.ca.gov/.
EU CLP
DANGER
H315 - Causes skin irritation. H317 - May cause an allergic skin reaction. H318 - Causes serious eye damage.
H371 - May cause damage to organs. H341 - Suspected of causing genetic defects H350 - May cause cancer.
Combustible liquid. P302 + P352 - IF ON SKIN: Wash with plenty of soap and water. P332 + P313 - If skin
irritation occurs: Get medical advice/ attention. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water
for several minutes. Remove contact lenses, if present and. easy to do. Continue rinsing. P310 - Immediately call
a POISON CENTER or doctor/ physician P308 + P313 - IF exposed or concerned: Get medical advice/ attention.
P280 - Wear protective gloves/ protective clothing/ eye protection/ face protection.
Additional EU labelling
Restricted to professional users
Order Information
Product Size Qty. REF
Formal-Fixx Ready-to-Use 2.64 gal. (10 L) 2/cs. 9990234
Formal-Fixx Ready-to-Use 5 gal. (19 L) Ea. 6764240
Wrench for 5 gal. (19 L) Carboy Ea. B1000722
Formal-Fixx Ready-to-Use, pre-lled cups 20 mL lled to 10 mL 180 cups/cs. 9990910
Formal-Fixx Ready-to-Use, pre-lled cups 60 mL lled to 30 mL 125 cups/cs. 9990914
Formal-Fixx Ready-to-Use, pre-lled cups 90 mL lled to 45 mL 125 cups/cs. 9990916
Formal-Fixx Ready-to-Use, pre-lled cups 120 mL lled to 60 mL 125 cups/cs. 9990918
Formal-Fixx Concentrate 1 L (makes 5 L) 2/cs 9990244
Formal-Fixx Concentrate 1 gal. (makes 5 gal.) Ea. 6764254
Formal-Fixx Ready-to-Use 5 Liter bottle 4/cs. 6764215
Syntri Safeguard™*
Formal-Fixx Ready-to-Use 5 Liter bottle 4/cs. 6764215SS
* For further instructions on how to use the Syntri Safeguard products please consult the Thermo Scientic Revos
user’s manual
238988 R10/18
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