NeuroNexus dDrive is a versatile and precise microdrive designed for chronic in vivo electrophysiological recordings in behaving animals. It features a compact and lightweight design, allowing for stable and minimally invasive recordings. The dDrive provides high-resolution electrode positioning with a 250 µm adjustment per turn, enabling researchers to target specific brain regions with precision.
NeuroNexus dDrive is a versatile and precise microdrive designed for chronic in vivo electrophysiological recordings in behaving animals. It features a compact and lightweight design, allowing for stable and minimally invasive recordings. The dDrive provides high-resolution electrode positioning with a 250 µm adjustment per turn, enabling researchers to target specific brain regions with precision.
dDrive User
Instructions
Updated March 03, 2022
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
dDRIVE SETUP INSTRUCTIONS
Read this manual carefully before planning your surgery.
Before implanting this device, you will need to gather
additional tools and perform a craniotomy.
Microdrive screwdriver kit:
•#0 Phillips Screwdriver
•1.8 mm Slot Screwdriver
• 0.9 mm Hex Screwdriver
Required Additional Tools:
• Dental cement
• Cement Applicator(s)
• Flush Cutters / Wire Cutters
Suggested Additional Tools:
• Third Hand / Helping Hand
• Tweezers
General surgical guidelines and craniotomy instructions can
be found here:
https://www.neuronexus.com/files/technicalsupportdocuments/General-Surgery-Guidlines.pdf
p.2
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
p.3
dDRIVE SETUP INSTRUCTIONS
Remove the device from its shipping holder by loosening the indicated screw
1 with the provided #0 Phillips screwdriver. Do not touch the silicon electrode.
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
dDRIVE SETUP INSTRUCTIONS
Attach an M2 threaded stereotaxic rod. This rod is coaxial with the electrode
and will be used to manipulate and implant the device during this procedure.
p.4
2
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
dDRIVE SETUP INSTRUCTIONS
Attach the 2 mm rod to your stereotaxic inserter over
your prepared craniotomy. Lower the device along the
insertion path until it meets the skull. Depending on your
electrode offset, the shanks may be partially implanted
during this process.
p.5
3
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
4
dDRIVE SETUP INSTRUCTIONS
p.6
Prepare a small amount
of dental cement. The
first application of cement
is only meant to hold the
drive during headcap
installation and should be
minimal. Cement must
not be applied outside the
indicated area.
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
dDRIVE SETUP INSTRUCTIONS
p.7
Apply a small amount of cement to the knurl to adhere the drive to the skull.
5
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
dDRIVE SETUP INSTRUCTIONS
the package holder downward (towards the skull) in its track to create slack
6 Loosen the package holder screw with the provided #0 Phillips screwdriver
. Slide
in the flex cable.
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
p.8
dDRIVE SETUP INSTRUCTIONS
p.9
7Remove the package from its holder. A helping hand/third hand may be used to
keep the package in a fixed position (to avoid unnecessary stress on the flex
cable).
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
p.10
dDRIVE SETUP INSTRUCTIONS
8Using the provided 0.9 mm Hex screwdriver,
loosen the set screw on the rear of the drive
2-3 complete revolutions to release the drive
from its insertion holder. Retract the holder
away from the drive using your stereotaxic
frame.
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
p.11
dDRIVE SETUP INSTRUCTIONS
Suggested orientations –remove
the extra hooks by cutting
where indicated
Caps as provided
9Prepare the provided headcap. Depending on your desired connector
orientation, the extra hooks can be removed with flush cutters/wire cutters.
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
dDRIVE SETUP INSTRUCTIONS
p.12
Not fully seated Fully seated
Lower the protective cap
(shown with side hooks
removed) into place on top of
the drive, aligned as shown.
The cap must be fully seated
before continuing.
10
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
dDRIVE SETUP INSTRUCTIONS
11
p.13
Gather any exposed flex cable and place the connector into the remaining
hooks on the drive cap. Attach any exposed reference wires now.
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
dDRIVE SETUP INSTRUCTIONS
12
p.14
Prepare a batch of dental cement. Apply cement liberally to the perimeter of
the device, ensuring to bury any exposed flex cable or reference wires/
screws for protection. Any remaining knurl should be covered with dental
cement.
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
dDRIVE SETUP INSTRUCTIONS
13
p.15
After the cement is fully cured, the device is ready for use. Adjust the
electrode depth with the provided 1.8 mm slot screwdriver. The adjustment
screw pitch is 250 µm per turn.
Note the correct insertion direction! All microdrives are shipped in the
fully-retracted position. Attempting to retract beyond this position may
damage the device.
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
dDRIVE SETUP INSTRUCTIONS
NeuroNexus Technologies, Inc. ©2022 | 5200 S. State Street, Suite 200, Ann Arbor, Michigan USA
Telephone: +1.734.913.8858 | Fax: +1.734.786.0069 | [email protected]
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NeuroNexus dDrive is a versatile and precise microdrive designed for chronic in vivo electrophysiological recordings in behaving animals. It features a compact and lightweight design, allowing for stable and minimally invasive recordings. The dDrive provides high-resolution electrode positioning with a 250 µm adjustment per turn, enabling researchers to target specific brain regions with precision.
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