Quest Genetic Operating instructions

Brand: Quest

Model: Genetic

Type: Operating instructions

Quest Genetic: Unraveling Your Genetic Blueprint

Discover the power of genetic insights with Quest Genetic, your personal gateway to unlocking the mysteries of your DNA. Explore your genetic predispositions, gain valuable health insights, and make informed decisions about your well-being. With Quest Genetic, you can:

Uncover Your Ancestry: Trace your genetic roots and discover your unique heritage. Learn about the fascinating journey your ancestors undertook and connect with your global family.
Reveal Health Risks: Understand your genetic susceptibility to certain health conditions, including hereditary hemochromatosis. Be proactive in managing your health and take preventive measures to reduce risks.

Quest Genetic: Unraveling Your Genetic Blueprint

Uncover Your Ancestry: Trace your genetic roots and discover your unique heritage. Learn about the fascinating journey your ancestors undertook and connect with your global family.
Reveal Health Risks: Understand your genetic susceptibility to certain health conditions, including hereditary hemochromatosis. Be proactive in managing your health and take preventive measures to reduce risks.

Clinical recommendations Resources

Genetic Insights is a screening test and is

not intended for diagnosis.

It is important to review your patient’s

personal and family health history for

increased incidence or early onset of

health conditions, including hereditary

hemochromatosis, for accurate risk

assessment.

Have questions?

Call 1.866.GENE.INFO (1.866.436.3463) to speak to a specialized Quest genetic counselor or

geneticist available to healthcare providers to discuss test selection and results.

Consider referring your patient to a

genetic counselor if they have questions.

Genetic counselors can provide

counseling on the implications of this test

result and next steps for your patient.

Your patient can contact a genetic counselor through their online Genetic Insights dashboard at no

additional cost.

To ﬁnd a genetic counselor practicing in your patient’s area for an in-person session,

please visit FindAGeneticCounselor.NSGC.org

Next steps

Key results

A DNA variant associated with being a carrier of HFE-associated hemochromatosis was found in the HFE gene.

People with HFE-associated hemochromatosis, also known as hereditary hemochromatosis, have a increased risk of iron overload.

Carriers do not have the condition and are likely not at increased risk for iron overload.

Visit QuestDiagnostics.com/Genetic-Health-Screening for more information about this test.

Genetic Insights: quick reference

guide for healthcare providers

This guide is intended to facilitate a discussion between a provider and their patient.

Genetic Insights test results: Hereditary hemochromatosis - carrier

Patient conversation starters:

Patient conversation starters

summarize the preceding information

in plain language to support

meaningful conversations between

you and your patient.

FindAGeneticCounselor.NSGC.org

Your Genetic Insights test is a screening test. Your result indicates you are a

carrier for hereditary hemochromatosis. As a next step, let’s review your personal

and family health history and address any questions or concerns you might have.

You may want to talk with a genetic counselor. Genetic counselors are experts in

genetics and can help you understand this result.

You can access a genetic counselor through your Genetic Insights dashboard at no

additional cost to you, and we can discuss a referral to a local genetic counselor.

What is hereditary hemochromatosis?

HFE-associated hemochromatosis (also known as hereditary

hemochromatosis) is an inherited condition characterized by

increased absorption of dietary iron which may lead to organ

damage, including liver cirrhosis, if left untreated.1

Not all people with hereditary hemochromatosis will develop

iron overload or associated symptoms and complications.1

Treatment is available for those who do.2,3

The most common type of hereditary hemochromatosis is

caused by a DNA variant in each copy of the HFE gene.1

People who are carriers have a variant in just 1 copy of the HFE

gene and are most likely not at increased risk for iron overload

due to HFE-associated hemochromatosis.1,2

Regardless of this result, personal and family history are

important risk factors for iron overload.1,2

What this result means for family members

HFE-associated hemochromatosis is an autosomal recessive

condition. Family members may have the same DNA variant.

The variant was most likely inherited from a parent who is at

least a carrier of HFE-associated hemochromatosis. Siblings

and other relatives may also be carriers.

People who are carriers can pass the variant on to their

children. If the carrier’s partner (or sperm/egg donor) is also a

carrier of HFE-associated hemochromatosis, then each child

they have has a 1 in 4 chance of having the condition.

People who are carriers may wish to share their test results

with family members so they may consider discussing

hereditary hemochromatosis with their healthcare provider.

Patient conversation starters:

Hereditary hemochromatosis is an inherited condition that

can cause too much iron in the blood and body. If not treated,

the iron can build up over time and can cause damage to

certain organs.

Hereditary hemochromatosis is caused by having a DNA

variant in each copy of the HFE gene.

People who have a DNA variant in only 1 copy of the HFE gene

are carriers of the condition. Carriers do not have the condition

and are unlikely to be at increased risk for iron buildup.

Patient conversation starters:

Hereditary hemochromatosis runs in families.

That means your family members may have the same DNA

variant in their HFE gene. You most likely inherited this variant

from 1 of your parents. Your siblings may also be carriers.

You may want to share this result with your family

members so they can consider talking to their doctor about

hereditary hemochromatosis.

Additional resources

The following advocacy groups have additional information and resources about

hereditary hemochromatosis:

American Liver Foundation: LiverFoundation.org

Iron Disorders Institute, Hemochromatosis.org: Hemochromatosis.org

QuestDiagnostics.com

Quest, Quest Diagnostics, any associated logos, and all associated Quest Diagnostics registered or unregistered trademarks are the property of Quest Diagnostics.

References

1. Barton JC, Edwards CQ. HFE Hemochromatosis. April 3, 2000. Updated December 6, 2018. In: Adam MP, Ardinger HH, Pagon RA, et al, editors. GeneReviews®

[Internet]. University of Washington, Seattle; 1993-2022. https://www.ncbi.nlm.nih.gov/books/NBK1440/

2. Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS. Diagnosis and Management of Hemochromatosis: 2011 Practice Guideline by the American Association for

the Study of Liver Diseases. Hepatology. 2011;54(1):328-343. doi:10.1002/hep.24330

3. Kowdley KV, Brown KE, Ahn J, Sundaram V. ACG Clinical Guideline: Hereditary Hemochromatosis. Am J Gastroenterol. 2019;114(8):1202-1218. Published correction:

Am J Gastroenterol. 2019;114(12):1927. doi:10.14309/ajg.0000000000000315

This information is not a substitute for medical advice, diagnosis, or treatment. The diagnosis or treatment of any disease or condition may be based on personal

history, family history, symptoms, a physical examination, laboratory test results, and other information considered important by a healthcare provider.

Individuals should talk with a healthcare provider about the meaning of genetic test results and before stopping, starting, or changing any medication or treatment.

Genetic Insights is a test developed and performed by Quest Diagnostics. The test results are not diagnostic and do not determine overall chances of developing a

disease or health condition. The tests are not cleared or approved by the US Food and Drug Administration.

Quest Genetic Operating instructions

Brand: Quest

Model: Genetic

Type: Operating instructions

Quest Genetic: Unraveling Your Genetic Blueprint

Uncover Your Ancestry: Trace your genetic roots and discover your unique heritage. Learn about the fascinating journey your ancestors undertook and connect with your global family.
Reveal Health Risks: Understand your genetic susceptibility to certain health conditions, including hereditary hemochromatosis. Be proactive in managing your health and take preventive measures to reduce risks.

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Quest Genetic Operating instructions

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