Roche cobas 8000 / ISE Module User manual

Category
Measuring, testing & control
Type
User manual
cobas
®
8000 modular analyzer
series
Operator’s Manual – Version 5.4
Software Version 06-07
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
2
Publication information
Edition notice This publication is intended for operators of the
cobas
®
8000 modular analyzer series.
Publication
version
Software version Revision date Change description
1.0 01–01 2009-06 First version
2.0 02–01 2010-01 e 602 module added
3.0 03–01 2010-10 c 702 module added
4.0 04–01 2013-04 General update including, by way of example:
o New software features such as review of calibrator status,
PT link, rack unloading, change rack priority, reagent
cassette masking
o Revised software features such as download of
applications, calibrators, and QC material
o Hitergent was replaced by EcoTergent
4.0.1 04–01 2013-05 Manual cleaning revised
4.0.2 04–01 2013-06 Cleaning of pipetter probes revised
4.1 04–02 2013-11 o Changed ISE measuring ranges
o Use of different sample tubes on a rack
o Other changes and corrections
4.2 05–01 2014-10 New software features added
u What is new in publication version 4.2? (22)
5.0 06–02 2016-05 Publication redesigned according to the new Roche
documentation concept.
e 801 module added.
u What is new in publication version 5.0? (22)
5.1 06–03 2016-10 o Inclusion of information on the ISE support box
o Inclusion of the addendum "Cleaning rack trays"
o New section about fluorinated greenhouse gas
o Updated cobas link information
o Minor changes throughout the document
u What is new in publication version 5.1? (21)
5.2 06–05 2017-12 o Inclusion of the addendum "Sample foam detection"
o Inclusion of the addendum 1.0 to Operator’s Manual
version 5.1 (specifications of radio equipment)
o Minor changes throughout the document
u What is new in publication version 5.2? (21)
5.3 06–06 2018-12 o Inclusion of the addendum 1.0 to Operator's Manual
version 5.2 (instrument approvals)
o Inclusion of the addendum 1.0 to Safety Guide version 5.2
(cyber security)
o Inclusion of information on extended power off for 2-17
days procedure
o Minor changes throughout the document
u What is new in publication version 5.3? (20)
5.4 06–07 2019-10 o Warning message in Safety guide added about sharps,
rough edges, and/or moving parts.
u What is new in publication version 5.4? (20)
y Revision history
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
3
The cobas
®
8000 modular analyzer series is composed of
2 main components:
• The instrument includes the analytical modules, the
control unit, and other core components.
•The cobas
®
8000 data manager consists of a PC
which coordinates data in real time between the
instrument and the host.
Every effort has been made to ensure that all the
information contained in this publication is correct at the
time of publishing. However, the manufacturer of this
product may need to update the publication information
as output of product surveillance activities, leading to a
new version of this publication.
Where to find information The Online Help contains all information about the
product, including the following:
• Routine operation
• Maintenance
• Safety
• Troubleshooting information
• A software reference
• Configuration information
• Background information
The Safety Guide contains important safety information.
You must read the Safety Guide before operating the
instrument.
The Quick Reference Guide provides you with an
overview of pre-routine and routine tasks on the data
manager and instrument.
The Operator’s Manual focuses on routine operation
and maintenance. The chapters are organized according
to the normal operation workflow.
A separate Operator’s Manual is available for the
cobas
®
8000 data manager.
The PC manufacturer’s manual contains all information
about the control unit hardware.
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
4
!
General attention
To avoid serious or fatal injury, ensure that you are
familiar with the system and safety information before you
use the system.
r Pay particular attention to all safety precautions.
r Always follow the instructions in this publication.
r Do not use the instrument in a way that is not
described in this publication.
r Store all publications in a safe and easily retrievable
place.
Training Do not carry out operation tasks or maintenance actions
unless you have received training from Roche
Diagnostics. Leave tasks that are not described in the
user documentation to trained Roche Service
representatives.
Screenshots The screenshots in this publication have been added
exclusively for illustration purposes. Configurable and
variable data, such as tests, results, or path names visible
therein must not be used for laboratory purposes.
Warranty Any customer modification to the system renders the
warranty or service agreement null and void.
For conditions of warranty, contact your local sales
representative or refer to your warranty contract partner.
Always leave software updates to a Roche Service
representative or perform such updates with their
assistance.
Copyright © 2007–2019, Roche Diagnostics GmbH.
All rights reserved.
License information
cobas
®
8000 modular analyzer series software is
protected by contract law, copyright law, and
international treaties. cobas
®
8000 modular analyzer
series contains a user license between F. Hoffmann-La
Roche Ltd. and a license holder, and only authorized
users may access the software and use it. Unauthorized
use and distribution may result in civil and criminal
penalties.
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
5
License agreement for UltraVNC software and
Linux Kernel
UltraVNC and Linux Kernel are pieces of free software for
all commercial uses, which are installed on the control
unit PC.
You can redistribute the software and/or modify it under
the terms of the GNU General Public License (version 2 or
later), as published by the Free Software Foundation. A
copy of the GNU General Public License (version 2) is
stored on the control unit PC. The path for the license is
C:\Program Files\uvnc bvba\UltraVNC.
The software is distributed without warranty. There is no
implied warranty of merchantability or fitness for a
particular purpose. For more information, see the GNU
General Public License at http://www.gnu.org/licenses.
The source code for the software is stored on the control
unit PC. The path for the source code is
C:\DriversAndTools\UltraVNC.
Open Source and Commercial Software
cobas
®
8000 modular analyzer series may include
components or modules of commercial or open-source
software. For further information on the intellectual
property and other warnings, as well as licenses
pertaining to the software programs included in
cobas
®
8000 modular analyzer series, refer to the
electronic distribution included with this product.
This open source and commercial software and
cobas
®
8000 modular analyzer series as a whole can
constitute a device regulated in accordance with
applicable law. For more detailed information, refer to the
user documentation and labeling.
Note that the respective authorization is no longer valid
according to the corresponding legislation should any
unauthorized changes be made to cobas
®
8000 modular
analyzer series.
Trademarks The following trademarks are acknowledged:
COBAS, COBAS C, COBAS E, COBAS INTEGRA, and LIFE
NEEDS ANSWERS are trademarks of Roche.
All other trademarks are the property of their respective
owners.
Feedback Every effort has been made to ensure that this publication
fulfills the intended purpose. All feedback on any aspect
of this publication is welcome and is considered during
updates. Contact your Roche representative, should you
have any such feedback.
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
6
Approvals
The cobas
®
8000 modular analyzer series meets the
requirements laid down in:
Directive 98/79/EC of the European Parliament and of the
Council of 27 October 1998 on in vitro diagnostic medical
devices.
Directive 2014/53/EU of the European Parliament and of
the Council of 16 April 2014 on the harmonization of the
laws of the Member States relating to the making
available on the market of radio equipment and repealing
Directive 1999/5/EC.
To view the full text of the 2014/53/EU declaration of
conformity, go to the Roche DiaLog Global Web Site
(https://dialog1.roche.com/) and choose the eLabDoc
link.
If you are unable to access Roche DiaLog, contact a
Roche Service representative.
Directive 2011/65/EU of the European Parliament and of
the Council of 8 June 2011 on the restriction of the use of
certain hazardous substances in electrical and electronic
equipment.
Compliance is provided by means of the Declaration of
Conformity.
The following marks demonstrate compliance:
Instrument approvals Furthermore, the instrument is manufactured and tested
according to the following international safety standards:
• IEC 61010-1
• IEC 61010-2-101
The instrument complies with the emission and immunity
requirements described in standard IEC 61326-2-
6/EN 61326-2-6.
For in vitro diagnostic use.
Complies with the IVD directive 98/79/EC on in vitro
diagnostic medical devices
Issued by Intertek for Canada and the US.
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
7
Contact addresses
Inside the European Union and
EFTA member states
Outside the European Union and
EFTA member states
Manufacturer of the
instrument
Hitachi High-Technologies
Corporation
1-24-14 Nishi-Shimbashi
Minato-ku Tokyo 105-8717
Japan
Manufacturer of
cobas
®
8000 data
manager
Roche Diagnostics GmbH
Sandhofer Strasse 116
68305 Mannheim
Germany
Authorized
representative
Roche Diagnostics GmbH
Sandhofer Strasse 116
68305 Mannheim
Germany
Manufactured by: Hitachi High-Technologies
Corporation
Manufactured for: Roche Diagnostics GmbH
Sandhofer Strasse 116
68305 Mannheim
Germany
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
8
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
9
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
10
Table of contents 11
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
Table of contents
Publication information 2
Contact addresses 7
Table of contents 11
Intended use 17
Symbols and abbreviations 17
What is new in publication version 5.4? 20
What is new in publication version 5.3? 20
What is new in publication version 5.2? 21
What is new in publication version 5.1? 21
What is new in publication version 5.0? 22
What is new in publication version 4.2? 22
Operation
5 Overview of the system
About the system 29
About the data manager 32
About the control unit 33
About the core components 35
About the cobas
®
ISE module 45
About the cobas c 701 module 58
About the cobas c 702 module 73
About the cobas c 502 module 92
About the cobas e 801 module 108
About the cobas e 602 module 129
6 Overview of operation
Overview of the user interface 149
Using the help system 162
Overview of cobas
®
link 168
7 Before operation
Quick reference: Main workflow 179
Starting the instrument 183
Troubleshooting system alarms 206
Preparing the instrument for operation 207
Measuring samples 221
8 Reagents
About reagent statuses 229
Working with reagent masking 232
Reagents of the ISE module 236
Reagents of the c 701 module 246
Reagents of the c 702 module 260
Reagents of the c 502 module 284
Reagents and consumables of the e 801
module 299
Reagents and consumables on the e 602
module 349
9Calibration
Calibration 373
Calibrating tests on the ISE and cobas c
modules 392
Calibrating tests on the cobas e modules 396
10 Quality control
About quality control (QC) 407
About QC types 409
Performing routine QC 411
Performing QC for standby reagents 413
Performing timeout QC 415
Performing QC after calibration 417
Performing manual QC 419
Checking QC results 421
Deactivating tests for QC material 423
Assigning non-barcoded QC material to rack
positions 424
Unloading auto QC racks from the auto QC
compartment 426
11 Orders and results
About sample processing 431
About data distribution 432
About barcode and non-barcode mode 434
Switching between barcode and non-barcode
mode 436
About the Rack Reception mode 438
Ordering tests 439
Working with barcodes 448
Loading samples 451
Processing samples 462
Working with sample results 470
Processing rerun tests 484
Unloading samples manually 489
About the Calibration Review submenu 490
12 After operation
Performing manual finalization on cobas e
modules 495
Performing data backup and archiving 498
Preparing the instrument for powering off 510
Powering off the instrument 511
13 Special operation
Overview of masking functions 527
Operating with a pre-analytical system 530
Operating the instrument in backup operating
mode 533
12 Table of contents
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
Maintenance
14 Overview of maintenance
Maintenance definitions 543
About performing maintenance 545
About modes for maintenance 546
About maintenance pipes and maintenance
pipe functions 558
Checking maintenance due time 567
Checking maintenance status 568
Requesting the maintenance report 569
List of maintenance actions 572
List of maintenance checks 577
List of maintenance schedules for all
modules 581
List of cleaning solutions 584
List of spare parts and replacement
intervals 585
List of maintenance videos 587
15 Maintenance of the core unit and the MSBs
List of maintenance actions on the core unit and
the MSBs 591
Daily maintenance of the core unit and the
MSBs 592
Monthly maintenance of the core unit and the
MSBs 594
Maintenance as required on the core unit and
the MSBs 599
16 Maintenance of the ISE module
List of maintenance actions on the ISE
module 607
Daily maintenance of the ISE module 609
Weekly maintenance of the ISE module 618
Monthly maintenance of the ISE module 621
Every 2 months maintenance of the ISE
module 628
Quarterly maintenance of the ISE module 634
Every 6 months maintenance of the ISE
module 640
Maintenance as required on the ISE
module 644
17 Maintenance of the c 701 and c 702 modules
List of maintenance actions on the c 701 and
c 702 modules 663
Daily maintenance of the c 701 and c 702
modules 665
Weekly maintenance of the c 701 and c 702
modules 673
Monthly maintenance of the c 701 and c 702
modules 684
Quarterly maintenance of the c 701 and c 702
modules 701
Every 6 months maintenance of the c 701 and
c 702 modules 706
Maintenance as required on the c 701 and
c 702 modules 712
18 Maintenance of the c 502 module
List of maintenance actions on the c 502
module 739
Daily maintenance of the c 502 module 741
Weekly maintenance of the c 502 module 748
Monthly maintenance of the c 502 module 755
Quarterly maintenance of the c 502
module 773
Every 6 months maintenance of the c 502
module 777
Maintenance as required on the c 502
module 783
19 Maintenance of the e 801 module
List of maintenance actions on the e 801
module 791
Daily maintenance of the e 801 module 793
Every 2 weeks maintenance of the e 801
module 798
Maintenance as required on the e 801
module 820
20 Maintenance of the e 602 module
List of maintenance actions on the e 602
module 845
Daily maintenance of the e 602 module 846
Weekly maintenance of the e 602 module 850
Every 2 weeks maintenance of the e 602
module 866
Quarterly maintenance of the e 602
module 870
Maintenance as required on the e 602
module 876
Table of contents 13
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
Appendix
21 Specifications
General specifications 895
Specifications of the control unit 901
Specifications of the core components 902
Specifications of the ISE module 904
Specifications of the cobas c modules 906
Specifications of the cobas e modules 909
List of available accessories and
consumables 912
Specifications of barcodes 922
22 Glossary
Index 931
14 Table of contents
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
Table of contents 15
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
16 Table of contents
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
17
Intended use
The cobas
®
8000 modular analyzer series is a fully
automated random-access software-controlled system
for immunoassays and photometric analysis intended for
qualitative and quantitative in vitro determinations using a
wide variety of tests.
The cobas
®
8000 modular analyzer series is an in vitro
diagnostic (IVD) medical equipment.
Symbols and abbreviations
Product names Except where the context clearly indicated otherwise, the
following product names and descriptors are used.
Symbols used in the publication
Product name Descriptor
cobas
®
8000 modular analyzer
series
System
cobas
®
8000 data manager
Data manager
cobas
®
ISE module
ISE module
cobas c 702 module c 702 module
cobas c 701 module c 701 module
cobas c 502 module c 502 module
cobas e 801 module e 801 module
cobas e 602 module e 602 module
cobas c pack reagent cassette
cobas e pack reagent cassette
cobas e pack green reagent cassette
cobas e flow cobas e flow test
Self-Contained ISE Support Box ISE support box
Sample Cup standard cup
Micro-Sample Cup micro cup
Sarstedt micro tube cryo cup
AssayTip/AssayCup tray magazine
WasteLiner solid waste box
y Product names
Symbol Explanation
o List item
u Related topics containing further information
q
Tip. Extra information on correct use or useful
hints
r Start of a task
I Extra information within a task
y Symbols used in the publication
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
18
Symbols used on products
Abbreviations The following abbreviations are used:
f Result of an action within a task
c Frequency of a task
n Duration of a task
d Materials that are required for a task
j Prerequisites of a task
u Topic. Used in cross-references to topics
p Task. Used in cross-references to tasks
w
Figure. Used in figure titles and cross-
references to figures
y
Table. Used in table titles and cross-references
to tables
z
Equation. Used in cross-references to
equations
Symbol Explanation
y Symbols used in the publication
Symbol Explanation
Global Trade Item Number
Quantity contained in the package
Quantity contained in the package
Orientation of the package during
transportation
Complies with the directive 2011/65/EU on
RoHS
y Symbols used on products
Abbreviation Definition
ACN Application Code Number
ANSI American National Standards Institute
CleanCell (CC) Wash solution for measuring cells after
measurement
y Abbreviations
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
19
CellCln1 Basic reaction cell wash solution
(NaOH-D)
CellCln2 Acid reaction cell wash solution
CFAS Calibrator for automated systems
(C.f.a.s.)
CSV Comma-separated values
CV Coefficient of variation
DIL ISE Diluent
EC European Community
ECL Electrochemiluminescence
ECO-D EcoTergent, additive to the incubation
bath to reduce surface tension
EFTA European Free Trade Association
EN European standard
ICVC Initial cassette volume check
IEC International Electrotechnical
Commission
IS ISE Internal Standard
ISE Ion-selective electrode
ISE COMP ISE Standard High, used as calibrator 3
ISE HIGH ISE Standard High, used as calibrator 2
ISE LOW ISE Standard Low, used as calibrator 1
IVD In vitro diagnostic
LED Light-emitting diode
LIS Laboratory information system
LLD Liquid level detection
MSB Module sample buffer
n/a Not applicable
NACL NaCl solution, used as diluent
NaOHD Wash solution for reagent probes and
reaction cells (D1)
ProCell (PC) Signal generating buffer for the ECL
detection
QC Quality control
RCM Reaction calculation mode
REF ISE Reference Electrolyte solution
RFID Radio-frequency identification
SCCS Additive to prevent reaction cell
carryover in long HbA1c batches (D3)
SD Standard deviation
SmpCln1 Basic sample probe wash solution
SmpCln2 Acid sample probe wash solution
SMS Wash solution for reagent probes and
reaction cells (D2)
Abbreviation Definition
y Abbreviations
Roche Diagnostics
cobas® 8000 modular analyzer series · Software Version 06-07 · Operator's manual · 5.4
20
What is new in publication version 5.4?
This section provides an overview of all major changes in
this publication and the software.
Safety Guide A warning message about Sharps, rough edges,
and/or moving parts has beed added to the Safety
guide.
What is new in publication version 5.3?
This section provides an overview of all major changes in
this publication and the software.
Safety Guide The safety precaution Bubbles or foam inside a cobas
c pack has been renamed to Bubbles or foam inside a
reagent cassette.
The description about Data security has been revised.
Instrument approvals The following standards have been deleted from the
instrument approvals:
• IEC 61010-2-081 and A1
• UL 61010-1
• CAN/CSA C22.2 No. 61010-1CAN/CSA C22.2
No. 61010-2-101CAN/CSA C22.2 No. 61010-2-081
u Instrument approvals (6)
Extended Power off and on The description for extended power-on and power-off
has been reworked.
u Powering on cobas e modules after extended power-
off (192)
u Powering off the instrument (511)
Reagent loader e 801 The description and naming of the status indicator and
reset button has been reworked.
New function, expired ProCell II M bottles are masked
automatically, has been described.
STAT Short turn-around time
SysClean ISE Cleaning Solution/Elecsys SysClean
WEEE Waste Electrical and Electronic
Equipment
Abbreviation Definition
y Abbreviations
  • Page 1 1
  • Page 2 2
  • Page 3 3
  • Page 4 4
  • Page 5 5
  • Page 6 6
  • Page 7 7
  • Page 8 8
  • Page 9 9
  • Page 10 10
  • Page 11 11
  • Page 12 12
  • Page 13 13
  • Page 14 14
  • Page 15 15
  • Page 16 16
  • Page 17 17
  • Page 18 18
  • Page 19 19
  • Page 20 20
  • Page 21 21
  • Page 22 22
  • Page 23 23
  • Page 24 24
  • Page 25 25
  • Page 26 26
  • Page 27 27
  • Page 28 28
  • Page 29 29
  • Page 30 30
  • Page 31 31
  • Page 32 32
  • Page 33 33
  • Page 34 34
  • Page 35 35
  • Page 36 36
  • Page 37 37
  • Page 38 38
  • Page 39 39
  • Page 40 40
  • Page 41 41
  • Page 42 42
  • Page 43 43
  • Page 44 44
  • Page 45 45
  • Page 46 46
  • Page 47 47
  • Page 48 48
  • Page 49 49
  • Page 50 50
  • Page 51 51
  • Page 52 52
  • Page 53 53
  • Page 54 54
  • Page 55 55
  • Page 56 56
  • Page 57 57
  • Page 58 58
  • Page 59 59
  • Page 60 60
  • Page 61 61
  • Page 62 62
  • Page 63 63
  • Page 64 64
  • Page 65 65
  • Page 66 66
  • Page 67 67
  • Page 68 68
  • Page 69 69
  • Page 70 70
  • Page 71 71
  • Page 72 72
  • Page 73 73
  • Page 74 74
  • Page 75 75
  • Page 76 76
  • Page 77 77
  • Page 78 78
  • Page 79 79
  • Page 80 80
  • Page 81 81
  • Page 82 82
  • Page 83 83
  • Page 84 84
  • Page 85 85
  • Page 86 86
  • Page 87 87
  • Page 88 88
  • Page 89 89
  • Page 90 90
  • Page 91 91
  • Page 92 92
  • Page 93 93
  • Page 94 94
  • Page 95 95
  • Page 96 96
  • Page 97 97
  • Page 98 98
  • Page 99 99
  • Page 100 100
  • Page 101 101
  • Page 102 102
  • Page 103 103
  • Page 104 104
  • Page 105 105
  • Page 106 106
  • Page 107 107
  • Page 108 108
  • Page 109 109
  • Page 110 110
  • Page 111 111
  • Page 112 112
  • Page 113 113
  • Page 114 114
  • Page 115 115
  • Page 116 116
  • Page 117 117
  • Page 118 118
  • Page 119 119
  • Page 120 120
  • Page 121 121
  • Page 122 122
  • Page 123 123
  • Page 124 124
  • Page 125 125
  • Page 126 126
  • Page 127 127
  • Page 128 128
  • Page 129 129
  • Page 130 130
  • Page 131 131
  • Page 132 132
  • Page 133 133
  • Page 134 134
  • Page 135 135
  • Page 136 136
  • Page 137 137
  • Page 138 138
  • Page 139 139
  • Page 140 140
  • Page 141 141
  • Page 142 142
  • Page 143 143
  • Page 144 144
  • Page 145 145
  • Page 146 146
  • Page 147 147
  • Page 148 148
  • Page 149 149
  • Page 150 150
  • Page 151 151
  • Page 152 152
  • Page 153 153
  • Page 154 154
  • Page 155 155
  • Page 156 156
  • Page 157 157
  • Page 158 158
  • Page 159 159
  • Page 160 160
  • Page 161 161
  • Page 162 162
  • Page 163 163
  • Page 164 164
  • Page 165 165
  • Page 166 166
  • Page 167 167
  • Page 168 168
  • Page 169 169
  • Page 170 170
  • Page 171 171
  • Page 172 172
  • Page 173 173
  • Page 174 174
  • Page 175 175
  • Page 176 176
  • Page 177 177
  • Page 178 178
  • Page 179 179
  • Page 180 180
  • Page 181 181
  • Page 182 182
  • Page 183 183
  • Page 184 184
  • Page 185 185
  • Page 186 186
  • Page 187 187
  • Page 188 188
  • Page 189 189
  • Page 190 190
  • Page 191 191
  • Page 192 192
  • Page 193 193
  • Page 194 194
  • Page 195 195
  • Page 196 196
  • Page 197 197
  • Page 198 198
  • Page 199 199
  • Page 200 200
  • Page 201 201
  • Page 202 202
  • Page 203 203
  • Page 204 204
  • Page 205 205
  • Page 206 206
  • Page 207 207
  • Page 208 208
  • Page 209 209
  • Page 210 210
  • Page 211 211
  • Page 212 212
  • Page 213 213
  • Page 214 214
  • Page 215 215
  • Page 216 216
  • Page 217 217
  • Page 218 218
  • Page 219 219
  • Page 220 220
  • Page 221 221
  • Page 222 222
  • Page 223 223
  • Page 224 224
  • Page 225 225
  • Page 226 226
  • Page 227 227
  • Page 228 228
  • Page 229 229
  • Page 230 230
  • Page 231 231
  • Page 232 232
  • Page 233 233
  • Page 234 234
  • Page 235 235
  • Page 236 236
  • Page 237 237
  • Page 238 238
  • Page 239 239
  • Page 240 240
  • Page 241 241
  • Page 242 242
  • Page 243 243
  • Page 244 244
  • Page 245 245
  • Page 246 246
  • Page 247 247
  • Page 248 248
  • Page 249 249
  • Page 250 250
  • Page 251 251
  • Page 252 252
  • Page 253 253
  • Page 254 254
  • Page 255 255
  • Page 256 256
  • Page 257 257
  • Page 258 258
  • Page 259 259
  • Page 260 260
  • Page 261 261
  • Page 262 262
  • Page 263 263
  • Page 264 264
  • Page 265 265
  • Page 266 266
  • Page 267 267
  • Page 268 268
  • Page 269 269
  • Page 270 270
  • Page 271 271
  • Page 272 272
  • Page 273 273
  • Page 274 274
  • Page 275 275
  • Page 276 276
  • Page 277 277
  • Page 278 278
  • Page 279 279
  • Page 280 280
  • Page 281 281
  • Page 282 282
  • Page 283 283
  • Page 284 284
  • Page 285 285
  • Page 286 286
  • Page 287 287
  • Page 288 288
  • Page 289 289
  • Page 290 290
  • Page 291 291
  • Page 292 292
  • Page 293 293
  • Page 294 294
  • Page 295 295
  • Page 296 296
  • Page 297 297
  • Page 298 298
  • Page 299 299
  • Page 300 300
  • Page 301 301
  • Page 302 302
  • Page 303 303
  • Page 304 304
  • Page 305 305
  • Page 306 306
  • Page 307 307
  • Page 308 308
  • Page 309 309
  • Page 310 310
  • Page 311 311
  • Page 312 312
  • Page 313 313
  • Page 314 314
  • Page 315 315
  • Page 316 316
  • Page 317 317
  • Page 318 318
  • Page 319 319
  • Page 320 320
  • Page 321 321
  • Page 322 322
  • Page 323 323
  • Page 324 324
  • Page 325 325
  • Page 326 326
  • Page 327 327
  • Page 328 328
  • Page 329 329
  • Page 330 330
  • Page 331 331
  • Page 332 332
  • Page 333 333
  • Page 334 334
  • Page 335 335
  • Page 336 336
  • Page 337 337
  • Page 338 338
  • Page 339 339
  • Page 340 340
  • Page 341 341
  • Page 342 342
  • Page 343 343
  • Page 344 344
  • Page 345 345
  • Page 346 346
  • Page 347 347
  • Page 348 348
  • Page 349 349
  • Page 350 350
  • Page 351 351
  • Page 352 352
  • Page 353 353
  • Page 354 354
  • Page 355 355
  • Page 356 356
  • Page 357 357
  • Page 358 358
  • Page 359 359
  • Page 360 360
  • Page 361 361
  • Page 362 362
  • Page 363 363
  • Page 364 364
  • Page 365 365
  • Page 366 366
  • Page 367 367
  • Page 368 368
  • Page 369 369
  • Page 370 370
  • Page 371 371
  • Page 372 372
  • Page 373 373
  • Page 374 374
  • Page 375 375
  • Page 376 376
  • Page 377 377
  • Page 378 378
  • Page 379 379
  • Page 380 380
  • Page 381 381
  • Page 382 382
  • Page 383 383
  • Page 384 384
  • Page 385 385
  • Page 386 386
  • Page 387 387
  • Page 388 388
  • Page 389 389
  • Page 390 390
  • Page 391 391
  • Page 392 392
  • Page 393 393
  • Page 394 394
  • Page 395 395
  • Page 396 396
  • Page 397 397
  • Page 398 398
  • Page 399 399
  • Page 400 400
  • Page 401 401
  • Page 402 402
  • Page 403 403
  • Page 404 404
  • Page 405 405
  • Page 406 406
  • Page 407 407
  • Page 408 408
  • Page 409 409
  • Page 410 410
  • Page 411 411
  • Page 412 412
  • Page 413 413
  • Page 414 414
  • Page 415 415
  • Page 416 416
  • Page 417 417
  • Page 418 418
  • Page 419 419
  • Page 420 420
  • Page 421 421
  • Page 422 422
  • Page 423 423
  • Page 424 424
  • Page 425 425
  • Page 426 426
  • Page 427 427
  • Page 428 428
  • Page 429 429
  • Page 430 430
  • Page 431 431
  • Page 432 432
  • Page 433 433
  • Page 434 434
  • Page 435 435
  • Page 436 436
  • Page 437 437
  • Page 438 438
  • Page 439 439
  • Page 440 440
  • Page 441 441
  • Page 442 442
  • Page 443 443
  • Page 444 444
  • Page 445 445
  • Page 446 446
  • Page 447 447
  • Page 448 448
  • Page 449 449
  • Page 450 450
  • Page 451 451
  • Page 452 452
  • Page 453 453
  • Page 454 454
  • Page 455 455
  • Page 456 456
  • Page 457 457
  • Page 458 458
  • Page 459 459
  • Page 460 460
  • Page 461 461
  • Page 462 462
  • Page 463 463
  • Page 464 464
  • Page 465 465
  • Page 466 466
  • Page 467 467
  • Page 468 468
  • Page 469 469
  • Page 470 470
  • Page 471 471
  • Page 472 472
  • Page 473 473
  • Page 474 474
  • Page 475 475
  • Page 476 476
  • Page 477 477
  • Page 478 478
  • Page 479 479
  • Page 480 480
  • Page 481 481
  • Page 482 482
  • Page 483 483
  • Page 484 484
  • Page 485 485
  • Page 486 486
  • Page 487 487
  • Page 488 488
  • Page 489 489
  • Page 490 490
  • Page 491 491
  • Page 492 492
  • Page 493 493
  • Page 494 494
  • Page 495 495
  • Page 496 496
  • Page 497 497
  • Page 498 498
  • Page 499 499
  • Page 500 500
  • Page 501 501
  • Page 502 502
  • Page 503 503
  • Page 504 504
  • Page 505 505
  • Page 506 506
  • Page 507 507
  • Page 508 508
  • Page 509 509
  • Page 510 510
  • Page 511 511
  • Page 512 512
  • Page 513 513
  • Page 514 514
  • Page 515 515
  • Page 516 516
  • Page 517 517
  • Page 518 518
  • Page 519 519
  • Page 520 520
  • Page 521 521
  • Page 522 522
  • Page 523 523
  • Page 524 524
  • Page 525 525
  • Page 526 526
  • Page 527 527
  • Page 528 528
  • Page 529 529
  • Page 530 530
  • Page 531 531
  • Page 532 532
  • Page 533 533
  • Page 534 534
  • Page 535 535
  • Page 536 536
  • Page 537 537
  • Page 538 538
  • Page 539 539
  • Page 540 540
  • Page 541 541
  • Page 542 542
  • Page 543 543
  • Page 544 544
  • Page 545 545
  • Page 546 546
  • Page 547 547
  • Page 548 548
  • Page 549 549
  • Page 550 550
  • Page 551 551
  • Page 552 552
  • Page 553 553
  • Page 554 554
  • Page 555 555
  • Page 556 556
  • Page 557 557
  • Page 558 558
  • Page 559 559
  • Page 560 560
  • Page 561 561
  • Page 562 562
  • Page 563 563
  • Page 564 564
  • Page 565 565
  • Page 566 566
  • Page 567 567
  • Page 568 568
  • Page 569 569
  • Page 570 570
  • Page 571 571
  • Page 572 572
  • Page 573 573
  • Page 574 574
  • Page 575 575
  • Page 576 576
  • Page 577 577
  • Page 578 578
  • Page 579 579
  • Page 580 580
  • Page 581 581
  • Page 582 582
  • Page 583 583
  • Page 584 584
  • Page 585 585
  • Page 586 586
  • Page 587 587
  • Page 588 588
  • Page 589 589
  • Page 590 590
  • Page 591 591
  • Page 592 592
  • Page 593 593
  • Page 594 594
  • Page 595 595
  • Page 596 596
  • Page 597 597
  • Page 598 598
  • Page 599 599
  • Page 600 600
  • Page 601 601
  • Page 602 602
  • Page 603 603
  • Page 604 604
  • Page 605 605
  • Page 606 606
  • Page 607 607
  • Page 608 608
  • Page 609 609
  • Page 610 610
  • Page 611 611
  • Page 612 612
  • Page 613 613
  • Page 614 614
  • Page 615 615
  • Page 616 616
  • Page 617 617
  • Page 618 618
  • Page 619 619
  • Page 620 620
  • Page 621 621
  • Page 622 622
  • Page 623 623
  • Page 624 624
  • Page 625 625
  • Page 626 626
  • Page 627 627
  • Page 628 628
  • Page 629 629
  • Page 630 630
  • Page 631 631
  • Page 632 632
  • Page 633 633
  • Page 634 634
  • Page 635 635
  • Page 636 636
  • Page 637 637
  • Page 638 638
  • Page 639 639
  • Page 640 640
  • Page 641 641
  • Page 642 642
  • Page 643 643
  • Page 644 644
  • Page 645 645
  • Page 646 646
  • Page 647 647
  • Page 648 648
  • Page 649 649
  • Page 650 650
  • Page 651 651
  • Page 652 652
  • Page 653 653
  • Page 654 654
  • Page 655 655
  • Page 656 656
  • Page 657 657
  • Page 658 658
  • Page 659 659
  • Page 660 660
  • Page 661 661
  • Page 662 662
  • Page 663 663
  • Page 664 664
  • Page 665 665
  • Page 666 666
  • Page 667 667
  • Page 668 668
  • Page 669 669
  • Page 670 670
  • Page 671 671
  • Page 672 672
  • Page 673 673
  • Page 674 674
  • Page 675 675
  • Page 676 676
  • Page 677 677
  • Page 678 678
  • Page 679 679
  • Page 680 680
  • Page 681 681
  • Page 682 682
  • Page 683 683
  • Page 684 684
  • Page 685 685
  • Page 686 686
  • Page 687 687
  • Page 688 688
  • Page 689 689
  • Page 690 690
  • Page 691 691
  • Page 692 692
  • Page 693 693
  • Page 694 694
  • Page 695 695
  • Page 696 696
  • Page 697 697
  • Page 698 698
  • Page 699 699
  • Page 700 700
  • Page 701 701
  • Page 702 702
  • Page 703 703
  • Page 704 704
  • Page 705 705
  • Page 706 706
  • Page 707 707
  • Page 708 708
  • Page 709 709
  • Page 710 710
  • Page 711 711
  • Page 712 712
  • Page 713 713
  • Page 714 714
  • Page 715 715
  • Page 716 716
  • Page 717 717
  • Page 718 718
  • Page 719 719
  • Page 720 720
  • Page 721 721
  • Page 722 722
  • Page 723 723
  • Page 724 724
  • Page 725 725
  • Page 726 726
  • Page 727 727
  • Page 728 728
  • Page 729 729
  • Page 730 730
  • Page 731 731
  • Page 732 732
  • Page 733 733
  • Page 734 734
  • Page 735 735
  • Page 736 736
  • Page 737 737
  • Page 738 738
  • Page 739 739
  • Page 740 740
  • Page 741 741
  • Page 742 742
  • Page 743 743
  • Page 744 744
  • Page 745 745
  • Page 746 746
  • Page 747 747
  • Page 748 748
  • Page 749 749
  • Page 750 750
  • Page 751 751
  • Page 752 752
  • Page 753 753
  • Page 754 754
  • Page 755 755
  • Page 756 756
  • Page 757 757
  • Page 758 758
  • Page 759 759
  • Page 760 760
  • Page 761 761
  • Page 762 762
  • Page 763 763
  • Page 764 764
  • Page 765 765
  • Page 766 766
  • Page 767 767
  • Page 768 768
  • Page 769 769
  • Page 770 770
  • Page 771 771
  • Page 772 772
  • Page 773 773
  • Page 774 774
  • Page 775 775
  • Page 776 776
  • Page 777 777
  • Page 778 778
  • Page 779 779
  • Page 780 780
  • Page 781 781
  • Page 782 782
  • Page 783 783
  • Page 784 784
  • Page 785 785
  • Page 786 786
  • Page 787 787
  • Page 788 788
  • Page 789 789
  • Page 790 790
  • Page 791 791
  • Page 792 792
  • Page 793 793
  • Page 794 794
  • Page 795 795
  • Page 796 796
  • Page 797 797
  • Page 798 798
  • Page 799 799
  • Page 800 800
  • Page 801 801
  • Page 802 802
  • Page 803 803
  • Page 804 804
  • Page 805 805
  • Page 806 806
  • Page 807 807
  • Page 808 808
  • Page 809 809
  • Page 810 810
  • Page 811 811
  • Page 812 812
  • Page 813 813
  • Page 814 814
  • Page 815 815
  • Page 816 816
  • Page 817 817
  • Page 818 818
  • Page 819 819
  • Page 820 820
  • Page 821 821
  • Page 822 822
  • Page 823 823
  • Page 824 824
  • Page 825 825
  • Page 826 826
  • Page 827 827
  • Page 828 828
  • Page 829 829
  • Page 830 830
  • Page 831 831
  • Page 832 832
  • Page 833 833
  • Page 834 834
  • Page 835 835
  • Page 836 836
  • Page 837 837
  • Page 838 838
  • Page 839 839
  • Page 840 840
  • Page 841 841
  • Page 842 842
  • Page 843 843
  • Page 844 844
  • Page 845 845
  • Page 846 846
  • Page 847 847
  • Page 848 848
  • Page 849 849
  • Page 850 850
  • Page 851 851
  • Page 852 852
  • Page 853 853
  • Page 854 854
  • Page 855 855
  • Page 856 856
  • Page 857 857
  • Page 858 858
  • Page 859 859
  • Page 860 860
  • Page 861 861
  • Page 862 862
  • Page 863 863
  • Page 864 864
  • Page 865 865
  • Page 866 866
  • Page 867 867
  • Page 868 868
  • Page 869 869
  • Page 870 870
  • Page 871 871
  • Page 872 872
  • Page 873 873
  • Page 874 874
  • Page 875 875
  • Page 876 876
  • Page 877 877
  • Page 878 878
  • Page 879 879
  • Page 880 880
  • Page 881 881
  • Page 882 882
  • Page 883 883
  • Page 884 884
  • Page 885 885
  • Page 886 886
  • Page 887 887
  • Page 888 888
  • Page 889 889
  • Page 890 890
  • Page 891 891
  • Page 892 892
  • Page 893 893
  • Page 894 894
  • Page 895 895
  • Page 896 896
  • Page 897 897
  • Page 898 898
  • Page 899 899
  • Page 900 900
  • Page 901 901
  • Page 902 902
  • Page 903 903
  • Page 904 904
  • Page 905 905
  • Page 906 906
  • Page 907 907
  • Page 908 908
  • Page 909 909
  • Page 910 910
  • Page 911 911
  • Page 912 912
  • Page 913 913
  • Page 914 914
  • Page 915 915
  • Page 916 916
  • Page 917 917
  • Page 918 918
  • Page 919 919
  • Page 920 920
  • Page 921 921
  • Page 922 922
  • Page 923 923
  • Page 924 924
  • Page 925 925
  • Page 926 926
  • Page 927 927
  • Page 928 928
  • Page 929 929
  • Page 930 930
  • Page 931 931
  • Page 932 932
  • Page 933 933
  • Page 934 934
  • Page 935 935
  • Page 936 936
  • Page 937 937
  • Page 938 938
  • Page 939 939
  • Page 940 940
  • Page 941 941
  • Page 942 942
  • Page 943 943
  • Page 944 944
  • Page 945 945
  • Page 946 946
  • Page 947 947
  • Page 948 948
  • Page 949 949
  • Page 950 950
  • Page 951 951
  • Page 952 952
  • Page 953 953
  • Page 954 954

Roche cobas 8000 / ISE Module User manual

Category
Measuring, testing & control
Type
User manual

Ask a question and I''ll find the answer in the document

Finding information in a document is now easier with AI