Siemens ADVIA 2400 User manual

ADVIA

®

2400 Chemistry System

Operator's Guide

073D0403-01 Rev. A, 2009-06

The ADVIA

®

2400 Chemistry system is for in vitro diagnostic use.

The information in this guide was correct at the time of release. However,

Siemens Healthcare Diagnostics continues to improve products and reserves the right to

change specifications, equipment, and maintenance procedures at any time without

notice.

If the system is used in a manner not specified by Siemens, the protection provided by

the equipment may be impaired. Observe all warning and hazard statements.

The ADVIA Chemistry system is manufactured in Japan for

Siemens.

THE UNIVERSAL RACK HANDLING SYSTEM IS MANUFACTURED IN GERMANY FOR

S

IEMENS.

O

RIGIN: JAPAN

Copyright and trademarks

ADVIA Centaur and ADVIA are trademarks of Siemens Healthcare Diagnostics.

Acrobat is a trademark of Adobe Systems Incorporated, San Jose, CA.

Clorox is a trademark of The Clorox Company, Oakland, CA.

Windows is a trademark of Microsoft Corporation.

No part of this manual or the products it describes may be reproduced by any means or

in any form without prior consent in writing from Siemens.

System Overview 3

Table of Contents

1 System Overview ...................................................................................................................................13

Operating principle ...................................................................................................................................13

Hardware Overview...................................................................................................................................14

Display and power panel..........................................................................................................................................15

Analyzer back view ..................................................................................................................................................15

Analyzer top view.....................................................................................................................................................16

Vertical Pumps.........................................................................................................................................................17

Horizontal Pumps ....................................................................................................................................................17

Workstation (front view) ...........................................................................................................................................18

PC (front view) .........................................................................................................................................................18

PC (back view).........................................................................................................................................................19

Sampling and analysis .............................................................................................................................................19

Sampling mechanisms.............................................................................................................................................19

Sampling operation .............................................................................................................................................19

Sample probe......................................................................................................................................................20

Sample pump ......................................................................................................................................................20

Clot detection...........................................................................................................................................................21

Reaction tray............................................................................................................................................................21

Reaction tray mixers ................................................................................................................................................22

Reaction tray wash mechanisms .............................................................................................................................22

Reaction tray washer operation ...............................................................................................................................24

Reaction tank...........................................................................................................................................................25

Sample tray..............................................................................................................................................................25

Sample tray .........................................................................................................................................................25

Sample tray operation .........................................................................................................................................26

Container types ...................................................................................................................................................26

SMP Pause .........................................................................................................................................................26

Spectrophotometer ..................................................................................................................................................27

Reagents ....................................................................................................................................................27

Reagent mechanisms ..............................................................................................................................................27

Reagent trays ..........................................................................................................................................................28

Reagent probes .......................................................................................................................................................29

Reagent pumps .......................................................................................................................................................29

Reagent tray operation ............................................................................................................................................30

Reagent container types .....................................................................................................................................30

RGT Pause button...............................................................................................................................................30

4 ADVIA 2400 Operator’s Guide

Sample aspiration and dilution mechanisms............................................................................................................30

Dilution tray mixer................................................................................................................................................31

Dilution tray mixer operation................................................................................................................................31

Dilution tray wash mechanisms...........................................................................................................................31

Dilution tray wash mechanism operation.............................................................................................................33

ISE (electrolyte analyzer)..........................................................................................................................34

Universal rack handler – functional description (optional) ..................................................................35

Software Overview ....................................................................................................................................36

Startup window ........................................................................................................................................................36

Operation Panel.......................................................................................................................................................36

Buttons ................................................................................................................................................................37

Status and message boxes .................................................................................................................................37

Other tasks accessed from System(s) on the Operation Panel...........................................................................37

Menu Panel..............................................................................................................................................................38

Other tasks accessed from System(s) on the Menu Panel..................................................................................38

Description of software windows............................................................................................................40

Request windows.....................................................................................................................................................40

Order Entry window.............................................................................................................................................40

Sample Log window ............................................................................................................................................40

Test Result Monitor window ................................................................................................................................41

Sample test status color codes ...........................................................................................................................41

Review/Edit window ............................................................................................................................................43

Reaction Monitor window ....................................................................................................................................43

RealTime Monitor window ...................................................................................................................................43

Print Report window*...........................................................................................................................................44

Test Select window*............................................................................................................................................44

Cup/Tube Assign window* ..................................................................................................................................44

Test Utilization Statistics window ........................................................................................................................44

Correlation window* ............................................................................................................................................45

Calibration windows.................................................................................................................................................45

View Calibration Curve window...........................................................................................................................45

Calibration/RBL History .......................................................................................................................................45

Sample Select window*.......................................................................................................................................46

Calibration Setup window* ..................................................................................................................................46

Maintenance windows..............................................................................................................................................46

System Startup/Shutdown Setting window..........................................................................................................46

User Maintenance window ..................................................................................................................................47

System Monitor window ......................................................................................................................................47

System Maintenance Monitor window.................................................................................................................47

Lamp Energy Monitor window .............................................................................................................................47

System Overview 5

ISE Operation window.........................................................................................................................................47

ISE Monitor window.............................................................................................................................................48

Manual Operation window...................................................................................................................................48

On-Line Monitor window......................................................................................................................................48

Error Report window* ..........................................................................................................................................49

Reagent windows ....................................................................................................................................................49

Reagent Inventory window..................................................................................................................................49

CTT Monitor window ...........................................................................................................................................49

Reagent Container Settings window ...................................................................................................................49

Active Test List window*......................................................................................................................................50

Reagent Information window* .............................................................................................................................50

Reagent Barcode Maintenance window*.............................................................................................................51

QC windows.............................................................................................................................................................51

ADVIA QC window ..............................................................................................................................................51

Real-time QC window..........................................................................................................................................52

Daily Precision Control window ...........................................................................................................................52

QC Cumulative window.......................................................................................................................................53

Control Data Setup window* ...............................................................................................................................53

Sample Select window*.......................................................................................................................................54

QC Sample Definition window* ...........................................................................................................................54

Setup windows.........................................................................................................................................................54

System Specification Settings window*...............................................................................................................54

Analytical Parameters (Chemistry) window*........................................................................................................55

System Test List window.....................................................................................................................................56

Analytical Parameters (Serum) window* .............................................................................................................56

Process Sequence window*................................................................................................................................57

Ratio Parameters window* ..................................................................................................................................57

Contamination Settings window*.........................................................................................................................57

Ctrl/Cal Sample Setup window* ..........................................................................................................................57

User Code Settings window*...............................................................................................................................58

New Test Definition window*...............................................................................................................................58

ISE Parameter Settings window* ........................................................................................................................58

Print Form Settings window* ...............................................................................................................................58

Online Settings window*......................................................................................................................................59

Alarm Buzzer Settings window* ..........................................................................................................................59

System Parameters Settings window*.................................................................................................................60

Reflex Test Settings window*..............................................................................................................................60

Other Tasks .............................................................................................................................................................60

Version Information window .................................................................................................................... 61

ADVIA o.p. ..........................................................................................................................................................61

6 ADVIA 2400 Operator’s Guide

Controller.............................................................................................................................................................61

Safety Message ..................................................................................................................................................61

Etc.......................................................................................................................................................................62

Memo ..................................................................................................................................................................62

Using online help ......................................................................................................................................62

Viewing the content .............................................................................................................................................63

2 Operating the System............................................................................................................................ 65

Start the System........................................................................................................................................65

Logging on ...............................................................................................................................................................65

Starting the system ..................................................................................................................................................65

Performing a system-assisted startup (Start set) .....................................................................................................66

Checking the analyzer .............................................................................................................................................67

Times required to perform prime, washes, and cell blank ...................................................................................71

Daily Operation..........................................................................................................................................72

Using workorders.....................................................................................................................................................72

Using host computer workorders.........................................................................................................................72

Creating workorders at the analyzer....................................................................................................................73

Creating multiple workorders...............................................................................................................................73

Deleting or changing test selectivity for multiple workorders ...............................................................................74

Creating a profile .....................................................................................................................................................75

Creating a load list ...................................................................................................................................................75

Loading patient samples..........................................................................................................................76

Loading patient samples on the STT .......................................................................................................................76

Loading patient samples on the optional universal rack handler..............................................................................77

Urgent samples and manual reruns are run from the onboard sampler (STT) ....................................................79

Starting the run ........................................................................................................................................................79

Running calibrators and reagent baselines (RBL)...............................................................................................80

Running control samples.....................................................................................................................................80

Running an interrupt (STAT) sample...................................................................................................................81

Monitoring an analysis while it is running.................................................................................................................82

Processing status................................................................................................................................................82

Sample information and system status................................................................................................................82

Monitoring samples loaded on the optional universal rack handler..........................................................................83

Using the Sample Log..............................................................................................................................................84

Viewing the sample log entries............................................................................................................................84

Searching the sample log....................................................................................................................................84

Deleting a specific sample log entry....................................................................................................................85

Deleting all sample log entries ............................................................................................................................85

Printing a list of the sample log entries................................................................................................................85

Exporting the sample log entries .........................................................................................................................86

System Overview 7

Reviewing the calibration results .............................................................................................................................86

Reviewing the sample results ..................................................................................................................................86

Reporting results......................................................................................................................................................86

Real-time reporting..............................................................................................................................................86

Batch transmission to a host computer ...............................................................................................................87

Printing sample data ................................................................................................................................................87

Batch Printing......................................................................................................................................................88

Shutting down the ADVIA Chemistry system ........................................................................................88

Examples of shutdown settings ...............................................................................................................................89

System available during the night .......................................................................................................................89

Automatic startup from the Sleep state ...............................................................................................................89

Automatic startup with analyzer power kept ON..................................................................................................89

Performing a system-assisted shutdown (Shutdown set) ........................................................................................90

Additional Operating Instructions........................................................................................................... 91

Switching Process Sequence and System Test List numbers.............................................................................91

Loading the reagent trays....................................................................................................................................91

Updating the Cumulative QC...............................................................................................................................91

Running automatic calibration ............................................................................................................................92

Using multiple reagent containers for the same test ...........................................................................................92

3 Calibration ..............................................................................................................................................93

Calibration overview .................................................................................................................................93

When to calibrate.....................................................................................................................................................93

Setting up the calibration .........................................................................................................................................93

Entering absolute or single-point (STD) calibration methods ..............................................................................93

Entering multi-standard calibration methods .......................................................................................................94

How to calibrate a multi-standard method ...........................................................................................................95

Running calibration ..................................................................................................................................................95

Reviewing the calibration .........................................................................................................................................96

4 Quality Control .......................................................................................................................................99

Quality control overview ..........................................................................................................................99

When to run control samples ...................................................................................................................................99

Setting up quality control .....................................................................................................................................99

Running the control samples...............................................................................................................................99

ADVIA QC window.................................................................................................................................................100

Reviewing the control results at different windows ................................................................................................100

5 Maintenance .........................................................................................................................................101

Maintenance schedule............................................................................................................................101

Daily maintenance...................................................................................................................................103

Inspecting and cleaning the probes .......................................................................................................................103

8 ADVIA 2400 Operator’s Guide

Cleaning the probes using automatic advance probe motion............................................................................103

Cleaning the probes using manual probe motion ..............................................................................................104

Probe cleaning procedure (optional method) ....................................................................................................106

Inspecting and cleaning the mixing rods and mixer wash cups .............................................................................107

Checking reagents and system solutions...............................................................................................................108

Inspecting and cleaning the reaction (WUD) and dilution (DWUD) cuvette washers .............................................108

Inspecting and cleaning the cuvette splash covers................................................................................................111

Inspecting and cleaning the probe wash cups .......................................................................................................112

Checking pumps for leaks......................................................................................................................................113

Checking the SP and DIP vertical pumps for leaks ...........................................................................................113

Checking other vertical pumps for leaks............................................................................................................114

Checking the horizontal pumps for leaks...........................................................................................................114

Performing the startup wash (WASH3)..................................................................................................................115

Performing the shutdown wash..............................................................................................................................117

Performing additional ISE electrode washes ....................................................................................... 118

Recording ISE slopes ............................................................................................................................................119

Weekly maintenance...............................................................................................................................119

Performing the weekly wash ..................................................................................................................................119

Checking and replenishing the lamp coolant .........................................................................................................121

Checking lamp energy ...........................................................................................................................................122

Reading lamp energy data ................................................................................................................................123

Measuring cuvette blanks ......................................................................................................................................124

Cell blank measurement results.............................................................................................................................124

Cleaning the analyzer and rack handler exterior panels ........................................................................................125

Monthly maintenance .............................................................................................................................126

Cleaning the turntable interiors (STT/CTT and RTT) .............................................................................................126

Cleaning the inside of the STT/CTT housing.....................................................................................................126

Cleaning the inside of the reagent tray refrigerated housing .............................................................................127

Cleaning or replacing the wash solution reagent containers (47 – 50) ..................................................................127

Cuvette wash and cuvette conditioner usage....................................................................................................128

Cleaning and replenishing the dilution bottle .........................................................................................................128

Cleaning and replenishing the cuvette wash bottle................................................................................................129

Cleaning the chiller filter.........................................................................................................................................130

Every 2 months maintenance ................................................................................................................ 131

Cleaning the dilution tray cuvettes .........................................................................................................................131

Cleaning and replenishing the cuvette conditioner bottle.......................................................................................132

Every 3 months maintenance ................................................................................................................ 133

Replacing the lamp ................................................................................................................................................133

Washing the ISE electrodes lines ..........................................................................................................................135

Every 4 months maintenance ................................................................................................................ 137

System Overview 9

Cleaning the ancillary reagent bottle filters ............................................................................................................137

Cleaning the pure-water bottle filter .......................................................................................................................137

Replacing the reaction and dilution cuvettes..........................................................................................................140

As required maintenance .......................................................................................................................143

Backing up system files .........................................................................................................................................143

Restoring system files............................................................................................................................................144

Replacing the SPP, RPP1, and RPP2 probes .......................................................................................................144

Remove the probe.............................................................................................................................................145

Install a new probe.................................................................................................................................................146

Replacing DPP probes equipped with crash detection ..........................................................................................147

Removing the DPP probe..................................................................................................................................147

Install the new probe..............................................................................................................................................149

Priming the system ................................................................................................................................................150

Replenishing the RRV (reaction) bath oil bottle .....................................................................................................150

Preventive cleaning of the wash station lines ........................................................................................................151

Washing all the ISE lines .......................................................................................................................................155

Washing the lines ..............................................................................................................................................156

Rinsing the lines................................................................................................................................................156

Priming and initializing the ISE module .............................................................................................................157

Conditioning the ISE Na and K electrodes.............................................................................................................157

Replacing ISE electrodes.......................................................................................................................................158

Removing electrodes.........................................................................................................................................159

Installing electrodes...........................................................................................................................................159

Priming the ISEs ...............................................................................................................................................159

Calibrating the ISEs...........................................................................................................................................160

Storing the reference electrode .........................................................................................................................160

Cleaning the dilution bowl and waste-drain nozzle ................................................................................................161

Cleaning the dilution bowl .................................................................................................................................161

Cleaning the waste-drain nozzle .......................................................................................................................162

Maintaining the ISE unit after the dilution bowl and waste-drain nozzle are clean ............................................163

Recovering from a power failure ............................................................................................................................163

Preparing the system for an expected power outage ........................................................................................163

Preparing the system for power return (if power was unexpectedly lost while system was on).........................163

Recovering from an unexpected power outage (after power returns,

when power was unexpectedly lost while system was on)...............................................................................164

6 Troubleshooting...................................................................................................................................166

7 File Management ..................................................................................................................................168

Saving the error log to a test file ........................................................................................................... 168

Capturing the error report:.................................................................................................................................168

Saving the test data from the User Maintenance window ......................................................................................169

10 ADVIA 2400 Operator’s Guide

Saving test data ................................................................................................................................................169

Saving reaction data in CSV format.......................................................................................................................170

Saving a data archive from User Maintenance window .........................................................................................171

Viewing data that was previously archived........................................................................................................172

8 System Setup .......................................................................................................................................174

Calibrating the touch screen monitor ................................................................................................... 174

Calibrating the touch screen..............................................................................................................................174

Configuring serum indices.....................................................................................................................174

Connecting to your host computer .......................................................................................................174

Cup/Tube Assignment ............................................................................................................................175

Setting up the ISE ...................................................................................................................................176

Activating the ISE..............................................................................................................................................176

Setting up ISE parameters ................................................................................................................................176

ISE calibration ...................................................................................................................................................176

Appendix A – Safety Information ..........................................................................................................178

Warning and hazard statements............................................................................................................178

Biohazard warning .................................................................................................................................................178

Electrical warning...................................................................................................................................................178

Laser warning ........................................................................................................................................................178

Household bleach warning.....................................................................................................................................179

Regulatory compliance ..........................................................................................................................................179

Laser information ..............................................................................................................................................179

Appendix B – Warranty and Support Information ............................................................................... 183

Limited Instrument Warranty and Service Delivery Policy ................................................................. 183

Warranty period .....................................................................................................................................................183

Additional service period........................................................................................................................................183

Service calls...........................................................................................................................................................184

Service during normal hours .............................................................................................................................184

Extent of a service call ......................................................................................................................................184

Service outside normal hours............................................................................................................................184

Replacement of parts.............................................................................................................................................184

Warranty and service exclusions ...........................................................................................................................184

Design changes and retrofitting of instruments .................................................................................................186

OSHA requirements ..........................................................................................................................................186

Software License ...................................................................................................................................................186

ADVIA Contact information ....................................................................................................................................187

Siemens Worldwide...........................................................................................................................................187

Appendix C –Customer replaceable parts............................................................................................188

Appendix D – Specifications..................................................................................................................190

System Overview 11

Specifications – all .................................................................................................................................................190

Appendix E – Symbols ........................................................................................................................... 194

Explanations of symbols associated with the ADVIA 2400 system ..................................................194

Warning and caution symbols................................................................................................................................194

System operation symbols.....................................................................................................................................195

System rating label symbols ..................................................................................................................................196

Hardware component symbols ..............................................................................................................................197

Ancillary reagent symbols ......................................................................................................................................197

Connector symbols ................................................................................................................................................198

System packaging label symbols...........................................................................................................................198

12 ADVIA 2400 Operator’s Guide

System Overview 13

1 System Overview

Figure 1-1. The ADVIA 2400 Chemistry System

The ADVIA

®

2400 Chemistry System is an automated, clinical chemistry analyzer that

can run tests on human serum, plasma, or urine in random access and batch modes at a

throughput rate of 1800 photometric tests per hour and 600 electrolyte tests per hour.

The ADVIA 2400 Chemistry System is for in vitro diagnostic use.

Operating principle

This sequence summarizes a photometric analysis on the Chemistry System:

1. The first reagent (R1) for a test is aspirated from reagent tray 1 and dispensed by the

reagent probe into the cuvette in the reaction tray.

2. Samples on the sample tray or rack handler are aspirated and diluted by the dilution

probe, then dispensed into cuvettes in the dilution tray.

3. The dilution mixer stirs the diluted sample.

4. The sample probe dispenses the required amount of diluted sample into the RRV

cuvettes (the reagent is already in the cuvettes).

The system can use the remaining diluted sample in the DTT cuvettes for additional

tests on a workorder, a rerun, dilution, or reflex testing.

5. The reaction mixer 1 mixes the first reagent and the sample.

6. The second reagent (R2) for a test is aspirated from reagent tray 2 and dispensed by

the reagent probe into the cuvette in the reaction tray.

7. The reaction mixer 2 mixes sample and reagent 1 and reagent 2.

8. The reaction takes place for the amount of time designated in the assay.

9. The spectrophotometer obtains the concentration data every six seconds.

14 ADVIA 2400 Operator’s Guide

For each measurement, the RRV moves the cuvettes in front of the

spectrophotometer.

10. Cell blank measurements are performed at each wavelength.

11. The RRV cuvettes are washed when measurement is complete.

12. When the analysis is complete, the lamp energy is checked at each wavelength.

Hardware Overview

1)

ISE location

2) Pure water bottle

3) Horizontal pumps

4) Vertical pumps

5) ISE buffer bottle

6) Reaction bath oil bottle

7) Isotonic saline diluent bottle

8) Cuvette detergent bottle

9) Cell conditioner bottle

10) Reaction bath oil heater

11) Refrigerator filter

12) Reaction bath oil pump

13) Reaction bath oil filter

14) Power panel

15) Display panel

Figure 1-2. Analyzer front view

System Overview 15

Display and power panel

1) READY lamp lights when the instrument is

ready.

2) START lamp lights when analysis is being

performed.

3) ALARM lamp lights when a problem occurs.

4) SYSTEM RESET button resets the computer

controlling the instrument (not normally used).

5) EMERGENCY STOP button is pressed to

stop the instrument in an emergency.

WARNING

If you stopped the system using the

Emergency Stop button, you must

perform a Weekly wash (WASH2)

prior to processing samples.

6) OPERATE/STANDBY switch turns the

analyzer power ON (OPERATE) or OFF

(STANDBY).

7) POWER lamp lights when the analyzer power

is ON.

Figure 1-3. Power panel

Analyzer back view

1) Main Power Switch

(powers the entire

instrument)

2) Water Supply and

Drainage Panel

3) Circuit breaker panel

Figure 1-4. Analyzer back view

16 ADVIA 2400 Operator’s Guide

External Circuits

Maximum supply current of outlet = 7.5 A at 100 Vac

Connected Equipment

Rack handler, Workstation

Analyzer top view

1) Sample tray

2) Sample-dilution probe (DPP)

3) Dilution mixer (DMIX)

4) Dilution tray (DTT)

5) Dilution washer (DWUD)

6) Sample probe (SPP)

7) Reaction tray washer (WUD)

8) Reaction mixer 2 (MIXR2)

9) Reaction mixer 1 (MIXR1)

10) Reaction tray (RRV)

11) Reagent tray 2 (RTT2)

12) Reagent tray 1 (RTT1)

13) Reagent probe 1 (RPP1)

14) Reagent probe 2 (RPP2)

Figure 1-5. Analyzer top view

System Overview 17

Vertical Pumps

1)

Dilution wash pump (DCP)

2) Dilution aspiration pump (DIP)

3) Dilution discharge pump (DOP)

4) Sampling wash pump (SCP)

5) Sampling pump (SP)

6) Reagent dispensing pump 1 (RP1)

7) Reagent wash pump 1 (RWP1)

8) Reagent dispensing pump 2 (RP2)

9) Reagent wash pump 2 (RWP2)

Figure 1-6. Vertical pumps

Horizontal Pumps

1) Dilution cuvette wash pump 1 (DWP1)

2) Dilution cuvette wash pump 1 (DWP2)

3) Dilution cuvette wash pump 1 (DWP3)

4) Dilution cuvette wash pump 1 (DWP4)

5) Switching valve (WCV2)

6) Switching valve (WCV1)

7) Reaction cuvette wash pump 1 (WP1)

8) Reaction cuvette wash pump 2 (WP2)

9) Reaction cuvette wash pump 3 (WP3)

10) Reaction cuvette detergent pump 1 (DTP1)

11) Reaction cuvette detergent pump 2 (DTP2)

Figure 1-7. Horizontal pumps

18 ADVIA 2400 Operator’s Guide

Workstation (front view)

1) Mouse

2) Touch-screen monitor

3) Printer

4) Keyboard

5) Personal computer (PC)

Figure 1-8. Workstation front view

PC (front view)

1)

Access door

2) CD-RW drive.

3) PC power switch. Used to turn ON or OFF the power

for the personal computer. Normally, it is left ON.

4) PC hard disk drive access lamp. Lights when reading

or writing to the PC hard disk.

5) PC power lamp. Lights when the power for the

personal computer is ON.

6) USB ports

Figure 1-9. PC front view

System Overview 19

PC (back view)

1)

PC power connector

2) Mouse connection

3) Keyboard connector

4) Communication port 1 (LIS-TDC)

5) Printer connector

6) LCD monitor connection

7) Analyzer Ethernet connection

8) Communication port 2 (URH)

9) Sleep ITF board potentiometer

Figure 1-10. PC back view

Sampling and analysis

Sampling mechanisms

The sample probe (SPP) aspirates sample from the dilution tray (DTT) and dispenses it

into reaction tray (RRV) cuvettes for analysis, according to specified conditions. The

sampling pump (SP) handles the aspiration and dispensing functions.

Sampling operation

At initialization, the SPP moves (in the up position) to the RRV cuvette, then stops above

the wash port. The pumps stop when the SPP is positioned over the RRV cuvettes.

Each sampling cycle consists of these steps:

1. The SPP moves to the aspiration position of the DTT and aspirates the sample.

2. The SPP moves back to the wash port, where deionized water washes the SPP’s

outside surface.

3. The SPP moves to the RRV and dispenses the sample into a cuvette.

4. The SPP returns to the wash port, where degassed water washes the inside and

outside of the SPP.

The SPP is now ready for another cycle.

20 ADVIA 2400 Operator’s Guide

If an assay is not running, you can operate the unit manually from the Manual Operation

window.

Sample probe

1) Wash port

2) Sampling probe (SPP)

Figure 1- 11 Sample probe

After aspiration, the SPP is lowered into an RRV cuvette, where it dispenses the sample.

The probe’s tip is 2 mm deep into the solution, ensuring that no droplet remains on the tip

after withdrawal.

NOTE: Unlike the sample-dilution (DPP) and the reagent probes (RPP1 and RPP2), the

SPP does not have liquid level sensing. This is because the DTT cuvettes are always the

same size.

Sample pump

1) Sampling pump (SP)

2) Sampling wash pump (SCP)

Figure 1- 12 Sample pumps

The sampling pump (SP) withdraws sample from DTT, and also dispenses sample into

the RRV cuvettes. The SPP executes both actions. During both actions, the sampling

pump valves (SPEV1 and SPEV2) are closed.

After the sample is aspirated, the SPP moves to the wash port, where its outside is

washed. Sample probe valve (SPEV2) is open during this process, allowing water to flow

over the outside of the SPP.

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Siemens ADVIA 2400 User manual

Siemens ADVIA 2400 User manual

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