• Ensure that the NObreathFlo
TM
and mouthpiece are
ed correctly to the front of the monitor.
• The NObreath® device should be held upright, this helps
the paent to maintain the correct ow rate by keeping
the ball elevated in the centre of the marked area on
the NObreathFlo
TM
.
• Two measurements, within 10% dierence of each
other, must be achieved before making a nal result.
• Paents should wait 3-5 minutes between tests in order
to allow NO levels to stabilise.
• Paents should not hold their breath before exhalaon,
they should take a deep breath in and then a long slow
exhalaon at 50ml/s as indicated on the NObreathFlo
TM
.
Bedfont® Scientic Ltd, Station Road, Harrietsham, Maidstone, Kent ME171JA
Issue 8- November 2017, Part No: LAB020 © Bedfont® Scientic Limited 2017.
Bedfont® Scientic Limited reserve the right to change or update this literature without prior notice.
Registered in: England and Wales. Registered No: 1289798
• Avoid alcohol consumpon for 24 hours prior to test
• No smoking for 12 hours before the test
• No food or drink to be consumed for 1 hour before the test
• No strenuous exercise to be undertaken for 1 hour before the test
Paent preparaon
When taking the test:
Factors directly
relang to asthma
Factors NOT directly
relang to asthma
Factors increasing
eNO
• Exacerbaons
• Low ICS compliance
• Poor inhaler technique
• Low asthma control
2
• Poor adherence
2
• Bronchial Hyper-Responsiveness
(BHR)
• Height, male gender
• Allergen exposure
• Atopy
• Diet
2
• Holding breath before a test
• Upper and lower respiratory tract
infecons
• Exercise
2
/hypervenlaon
• Cysc brosis
2
Factors decreasing
eNO
• Increased ICS treatment
2
• Leukotriene receptor antagonists
(LTRA) medicaon may have an
eect on lowering eNO
1
• Alchohol decreases eNO in
asthmacs but not in normal
individuals
1
• Good adherence
• Spirometry
• Smoke exposure
1
• Pulmonary hypertension
• Primary ciliry dyskinesia
1
1
Exhaled nitric oxide and the management of childhood
asthma – yet another promising biomarker “has been”
or a misunderstood gem Turner: Paed Respir Rev 2015;
16:88.
2
Yates, D. H., Kharitonov, S. A.,Robbins, R. A., Thomas, P.
S. and Barnes, P. J. (1996) ‘The eect of alcohol ingeson
on exhaled nitric oxide’, European Respiratory Journal,
9(6), pp. 1130–1133.